HRS participates in a number of genetic data consortia. The published results of these collaborations are listed below, with links to the HRS Bibliography. Several projects are still in progress, and will be added to this page upon publication.
Genetic Data Consortia
CHARGE
Cohorts for Heart and Aging Research in Genetic Epidemiology
Website: http://www.chargeconsortium.com/
Publications from the HRS Bibliography
Marouli E, Graff M, Medina-Gomez C, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017;542(7640):186-190. doi:10.1038/nature21039
Pattaro C, Teumer A, Gorski M, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016;7:10023. doi:10.1038/ncomms10023
Okbay A, Baselmans BML, De Neve J-E, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624-33. doi:10.1038/ng.3552
Barban N, Jansen R, de Vlaming R, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016;48(12):1462-1472. doi:10.1038/ng.3698
Matteini AM, Tanaka T, Karasik D, et al. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016;15(5):792-800. doi:10.1111/acel.12468
Liu C, Kraja AT, Smith JA, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016;48(10):1162-70. doi:10.1038/ng.3660
Demirkan A, Lahti J, Direk N, et al. Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med. 2016;46(8):1613-23. doi:10.1017/S0033291715002081
Davies G, Armstrong N, Bis JC, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015;20(2):183-92. doi:10.1038/mp.2014.188
Broer L, Buchman AS, Deelen J, et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015;70(1):110-8. doi:10.1093/gerona/glu166
Bihlmeyer NA, Brody JA, Smith AV, et al. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159. doi:10.1186/s12863-014-0159-7
Rietveld CA, Medland SE, Derringer J, et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013;340(6139):1467-71. doi:10.1126/science.1235488
COGENT
Continental Origins and Genetic Epidemiology Network
Publications from the HRS Bibliography
Franceschini N, Fox E, Zhang Z, et al. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet. 2013;93(3):545-54. doi:10.1016/j.ajhg.2013.07.010
GIANT
Genetic Investigation of Anthropometric Traits
Website: http://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_c…
Publications from the HRS Bibliography
Yengo L, Sidorenko J, Kemper KE, et al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Human Molecular Genetics. 2018;27(20):3641-3649. doi:10.1093/hmg/ddy271
Turcot V, Lu Y, Highland HM, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50(1):26-41. doi:10.1038/s41588-017-0011-x
Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-206. doi:10.1038/nature14177
ReproGen
Reproductive Genetics Consortium
Website: http://www.reprogen.org/
Publications from the HRS Bibliography
Day FR, Ruth KS, Thompson DJ, et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet. 2015;47(11):1294-303. doi:10.1038/ng.3412
ROHGen
Runs of Homozygosity Genetics Consortium
Publications from the HRS Bibliography
Joshi PK, Esko T, Mattsson H, et al. Directional dominance on stature and cognition in diverse human populations. Nature. 2015;523(7561):459-62. doi:10.1038/nature14618
SiGN
Stroke Genetics Network
Publications from the HRS Bibliography
Network NSG, Consortium ISG. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurology. 2016;15(2):174-184. doi:10.1016/S1474-4422(15)00338-5
SSGAC
Social Science Genetics Association Consortium
Website: http://www.thessgac.org/
Publications from the HRS Bibliography
Okbay A, Beauchamp JP, Fontana MA, et al. Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 2016;533(7604):539-42. doi:10.1038/nature17671
Weiss A, Baselmans BML, Hofer E, et al. Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet. 2016;19(5):407-17. doi:10.1017/thg.2016.65