The Polygenic Scores Data (PGS) V4 data is now available and include data for respondents who provided salivary DNA between 2006 and 2012. These scores help harmonize research across studies. PGS for each phenotype are based on a single, replicated genome-wide association study (GWAS). These scores are updated periodically as sufficiently large GWAS are published for new phenotypes or as meta-analyses for existing phenotypes are updated. This update includes the PGS for Educational Attainment including 23andMe summary statistics.
The Epigenetic Clocks V1 file is now available. A number of researchers have identified portions of the genome where DNA methylation (DNAm) changes are related to either age or, more recently, to health outcomes linked to age. The resulting “methylation clocks” combine information for a small number of CpGs (typically 100-500) to produce indicators of epigenetic aging. Thirteen epigenetic clocks have been constructed using the HRS DNAm data collected in 2016 (n=4,018) through the 2016 Venous Blood Study (VBS).