Association of a Genetic Risk Score with BMI along the Life-Cycle: Evidence from Several US Cohorts

TitleAssociation of a Genetic Risk Score with BMI along the Life-Cycle: Evidence from Several US Cohorts
Publication TypeReport
Year of Publication2020
AuthorsSanz-de-Galdeano, A, Terskaya, A, Upegui, A
Series TitleIZA Discussion Paper Series
Document NumberIZA DP No. 13671
InstitutionIZA Institute of Labor Economics
CityBonn, Germany
KeywordsAdd Health, BMI polygenic scores, Obesity
Abstract

We use data from the The National Longitudinal Study of Adolescent to Adult Health and
from the Health and Retirement Study to explore how the the effect of individuals’ genetic
predisposition to higher BMI —measured by BMI polygenic scores— changes over the lifecycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases
significantly as teenagers transition into adulthood (using the Add Health cohort, born
1974-83). However, this is not the case for individuals aged 55+ who were born in earlier
HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably
stable as they move into old-age.

URLhttp://ftp.iza.org/dp13671.pdf
Citation Key11043