@article {8133, title = {The impact of a cancer diagnosis on weight change: findings from prospective, population-based cohorts in the UK and the US}, journal = {Bmc Cancer}, volume = {14}, year = {2014}, note = {Times Cited: 0 0}, pages = {926-926}, publisher = {14}, abstract = {Background: Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts of older adults, we examined weight change in cancer survivors and cancer-free controls in relation to baseline weight status. Methods: In the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS), we identified participants diagnosed with cancer who had pre- and post-diagnosis BMI data (ELSA n = 264; HRS n = 2553), and cancer-free controls (ELSA n = 1538; HRS n = 4946). Repeated-measures ANOVAs tested three-way interactions by group (cancer/control), time (pre-/post-diagnosis), and pre-diagnosis weight status (normal-weight/overweight/obese). Results: Mean BMI change was -0.07 (SD = 2.22) in cancer survivors vs. 0.14 (SD = 1.11) in cancer-free controls in ELSA, and -0.20 (SD = 2.84) vs. 0.11 (SD = 0.93) respectively in HRS. Three-way interactions were significant in both cohorts (ELSA p = .015; HRS p .001). In ELSA, mean BMI change in normal-weight cancer survivors was 0.19 (SD = 1.53) compared with -0.33 (SD = 3.04) in obese survivors. In ELSA controls, the respective figures were 0.09 (SD = 0.81) and 0.16 (SD = 1.50). In HRS, mean change in normal-weight cancer survivors was 0.07 (SD = 2.30) compared with -0.72 (SD = 3.53) in obese survivors. In HRS controls, the respective figures were 0.003 (SD = 0.66) and 0.27 (SD = 1.27). Conclusion: Over a four-year period, in two cohorts of older adults, cancer survivors lost weight relative to cancer-free controls. However, cancer survivors who were obese pre-diagnosis were more likely to lose weight than healthy-weight survivors or obese adults without a cancer diagnosis. Whether this was due to differences in clinical status or deliberate lifestyle change triggered by the cancer diagnosis is not known. Further research is needed to establish why weight loss occurs more frequently in cancer survivors who were obese at diagnosis, and whether this has favourable effects on mortality.}, keywords = {Health Conditions and Status}, author = {Sarah E Jackson and Williams, Kate and Andrew Steptoe and Wardle, Jane} } @article {7974, title = {Predictors of Weight Loss in Obese Older Adults: Findings from the USA and the UK}, journal = {Obesity Facts}, volume = {7}, year = {2014}, note = {Export Date: 21 April 2014 Source: Scopus Article in Press}, pages = {102-110}, publisher = {7}, abstract = {Objective: To examine the prevalence and demographic predictors of clinically meaningful weight loss in community samples of obese older adults in the USA and the UK. Methods: Data were from obese older adults (BMI 30 kg/m2; age 52 years), free of a cancer diagnosis, from the Health and Retirement Study (HRS; n = 3398) and the English Longitudinal Study of Ageing (ELSA; n = 998). Weight change was assessed from 2004 to 2008. Multivariable logistic regression tested whether age, sex, ethnicity, marital status, education, or BMI predicted 5 weight loss. Results: Over a quarter (28.7 ) of obese participants from HRS and 16.6 from ELSA lost 5 weight. Being female (odds ratio (OR) = 1.31, 95 confidence interval (CI) = 1.11-1.54) and heavier (BMI 35 kg/m2) (OR = 1.60, 95 CI = 1.37-1.87) predicted weight loss in HRS. Trends were similar in ELSA (female: OR = 1.18, 95 CI = 0.83-1.69; BMI 35 kg/m2: OR = 1.24, 95 CI = 0.85-1.82). ORs were increased in 65-year-olds in HRS (OR = 1.55, 95 CI = 1.33-1.81), and reduced in married people in ELSA (OR = 0.69, 95 CI = 0.48-1.00). Neither education nor ethnicity predicted weight loss in either cohort. Conclusion: A high proportion of obese older adults experience clinically meaningful weight loss, but few demographic variables consistently predict weight loss in this population. 2014 S. Karger GmbH, Freiburg.}, keywords = {Adult children, Health Conditions and Status, Women and Minorities}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84897119471andpartnerID=40andmd5=f9f70f628dc5b0a20a721ff7288b13f4}, author = {Sarah E Jackson and Rebecca J. Beeken and Wardle, Jane} }