@article {10.1093/geronb/gbz156,
	title = {Mortality and Obesity among US Older Adults: The Role of Polygenic Risk},
	journal = {The Journals of Gerontology, Series B},
	volume = {76},
	year = {2021},
	pages = {343-347},
	abstract = {To examine the relationship between obesity and mortality as a function of polygenic risk for obesity among older US adults.Using data from the 1994-2014 Health and Retirement Study in conjunction with genome-wide data, we evaluated the risk of mortality as a function of obesity classification, an individual{\textquoteright}s polygenic risk score (PGS) for obesity, and their interaction, stratified by sex. We conducted our analyses using cox proportional hazard models.Among those with an average PGS for obesity (8,143 [68.8 \%]), obese I (HR = 0.7},
	keywords = {Mortality, Obesity, polygenic risk, Polygenic risk score},
	issn = {1079-5014},
	doi = {10.1093/geronb/gbz156},
	author = {Vinneau, Justin M and Huibregtse, Brooke M and Laidley, Thomas M and Joshua A Goode and Jason D Boardman}
}
@article {11455,
	title = {Utilizing genome wide data to highlight the social behavioral pathways to health: The case of obesity and cardiovascular health among older adults},
	journal = {Social Science \& Medicine},
	volume = {273},
	year = {2021},
	pages = {113766},
	abstract = {We use genome-wide data from the 1992{\textendash}2016 Health and Retirement Study (n = 12,090) to characterize obesity among older adults as genetically or socially oriented. To illustrate the significance of this approach for social epidemiological research, we deem those with the lowest genetic risk for obesity to be socially-behaviorally obese and obesity among those with the highest polygenic risk is characterized as genetically oriented. We then examine the association between obesity and four indicators of cardiovascular health (type-2 diabetes, hypertension, heart problems, and stroke) among those with low, average, and high genetic risk. Our results show that the association between obesity and cardiovascular health is significantly higher for those with the lowest genetic risk (e.g., social-behavioral obesity). We also demonstrate important sex differences such that this association is particularly strong for heart problems among men and hypertension and stroke among women. Our results further demonstrate the centrality of the social and behavioral determinants of health by utilizing detailed information across the human genome and add to both social and genetic epidemiology literatures.},
	keywords = {Behavioral genetics, Diabetes, GxE interaction, Health and Retirement Study, Heart problems, Hypertension, Obesity, Stroke},
	isbn = {0277-9536},
	doi = {https://doi.org/10.1016/j.socscimed.2021.113766},
	author = {Davidson, Trent and Vinneau-Palarino, Justin and Joshua A Goode and Jason D Boardman}
}
