@article {7524, title = {Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.}, journal = {Alzheimers Res Ther}, volume = {2}, year = {2010}, month = {2010 Jun 24}, pages = {19}, publisher = {2}, abstract = {

INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia.

METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression.

RESULTS: Treated stroke (odds ratio [OR] 3.8, 95\% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95\% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95\% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95\% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001).

CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia.

}, issn = {1758-9193}, doi = {10.1186/alzrt43}, url = {http://alzres.com/content/2/3/19}, author = {David J Llewellyn and Iain A Lang and Fiona E Matthews and Brenda L Plassman and Mary A M Rogers and Lewis B Morgenstern and Gwenith G Fisher and Mohammed U Kabeto and Kenneth M. Langa} }