@article {8608, title = {Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.}, journal = {Am J Hum Genet}, volume = {93}, year = {2013}, month = {2013 Sep 05}, pages = {545-54}, abstract = {

High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0~{\texttimes} 10(-8)) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability.

}, keywords = {Africa, African Continental Ancestry Group, Blood pressure, Cohort Studies, Databases, Genetic, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Reproducibility of Results}, issn = {1537-6605}, doi = {10.1016/j.ajhg.2013.07.010}, author = {Franceschini, Nora and Fox, Ervin and Zhang, Zhaogong and Edwards, Todd L and Michael A Nalls and Yun Ju Sung and Bamidele O Tayo and Yan V Sun and Gottesman, Omri and Adebawole Adeyemo and Andrew D Johnson and Young, J Hunter and Kenneth Rice and Duan, Qing and Chen, Fang and Yun Li and Tang, Hua and Myriam Fornage and Keene, Keith L and Andrews, Jeanette S and Jennifer A Smith and Jessica Faul and Guangfa, Zhang and Guo, Wei and Liu, Yu and Murray, Sarah S and Musani, Solomon K and Srinivasan, Sathanur and Digna R Velez Edwards and Wang, Heming and Becker, Lewis C and Bovet, Pascal and Bochud, Murielle and Broeckel, Ulrich and Burnier, Michel and Carty, Cara and Daniel I Chasman and Georg B Ehret and Chen, Wei-Min and Chen, Guanjie and Wei Chen and Ding, Jingzhong and Dreisbach, Albert W and Michele K Evans and Guo, Xiuqing and Melissa E Garcia and Jensen, Rich and Keller, Margaux F and Lettre, Guillaume and Lotay, Vaneet and Martin, Lisa W and Moore, Jason H and Alanna C Morrison and Thomas H Mosley and Ogunniyi, Adesola and Walter R Palmas and George J Papanicolaou and Alan Penman and Polak, Joseph F and Ridker, Paul M and Babatunde Salako and Andrew B Singleton and Daniel Shriner and Kent D Taylor and Ramachandran S Vasan and Kerri Wiggins and Williams, Scott M and Yanek, Lisa R and Wei Zhao and Alan B Zonderman and Becker, Diane M and Berenson, Gerald and Boerwinkle, Eric and Erwin P Bottinger and Cushman, Mary and Charles B Eaton and Nyberg, Fredrik and Gerardo Heiss and Joel N Hirschhron and Howard, Virginia J and Karczewsk, Konrad J and Lanktree, Matthew B and Liu, Kiang and Yongmei Liu and Ruth J F Loos and Margolis, Karen and Snyder, Michael and Psaty, Bruce M and Schork, Nicholas J and David R Weir and Charles N Rotimi and Sale, Michele M and Tamara B Harris and Sharon L R Kardia and Hunt, Steven C and Donna K Arnett and Redline, Susan and Cooper, Richard S and Neil Risch and Rao, D C and Rotter, Jerome I and Chakravarti, Aravinda and Reiner, Alex P and Levy, Daniel and Keating, Brendan J and Zhu, Xiaofeng} }