@article {9337,
	title = {Alzheimer{\textquoteright}s disease genetic risk variants beyond  APOE ε4 predict mortality},
	journal = {Alzheimer{\textquoteright}s \& Dementia: Diagnosis, Assessment \& Disease Monitoring},
	volume = {8},
	year = {2017},
	pages = {188-195},
	abstract = {We hypothesized that, like apolipoprotein E (APOE), other late-onset Alzheimer{\textquoteright}s disease (LOAD) genetic susceptibility loci predict mortality. Methods We used a weighted genetic risk score (GRS) from 21 non-APOE LOAD risk variants to predict survival in the Adult Changes in Thought and the Health and Retirement Studies. We meta-analyzed hazard ratios and examined models adjusted for cognitive performance or limited to participants with dementia. For replication, we assessed the GRS-longevity association in the Cohorts for Heart and Aging Research in Genomic Epidemiology, comparing cases surviving to age >=90 years with controls who died between ages 55 and 80 years. Results Higher GRS predicted mortality (hazard ratio = 1.05; 95\% confidence interval: 1.00{\textendash}1.10, P =.04). After adjusting for cognitive performance or restricting to participants with dementia, the relationship was attenuated and no longer significant. In case-control analysis, the GRS was associated with reduced longevity (odds ratio = 0.64; 95\% confidence interval: 0.41{\textendash}1.00, P =.05). Discussion Non-APOE LOAD susceptibility loci confer risk for mortality, likely through effects on dementia incidence.},
	keywords = {Alzheimer{\textquoteright}s disease, APoE4, Cognitive Ability, Genetics, Mortality, Risk Factors},
	issn = {23528729},
	doi = {10.1016/j.dadm.2017.07.002},
	url = {http://linkinghub.elsevier.com/retrieve/pii/S2352872917300416http://api.elsevier.com/content/article/PII:S2352872917300416?httpAccept=text/xmlhttp://api.elsevier.com/content/article/PII:S2352872917300416?httpAccept=text/plain},
	author = {Mez, Jesse and Jessica R Marden and Mukherjee, Shubhabrata and Stefan Walter and Laura E Gibbons and Alden L Gross and Laura B Zahodne and Paola Gilsanz and Brewster, Paul and Nho, Kwangsik and Paul K Crane and Eric B Larson and M. Maria Glymour}
}
