TY - JOUR T1 - New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. JF - Nature Human Behaviour Y1 - 2019 A1 - Evangelou, Evangelos A1 - Gao, He A1 - Chu, Congying A1 - Ntritsos, Georgios A1 - Blakeley, Paul A1 - Butts, Andrew R A1 - Pazoki, Raha A1 - Suzuki, Hideaki A1 - Koskeridis, Fotios A1 - Yiorkas, Andrianos M A1 - Karaman, Ibrahim A1 - Elliott, Joshua A1 - Luo, Qiang A1 - Aeschbacher, Stefanie A1 - Traci M Bartz A1 - Baumeister, Sebastian E A1 - Braund, Peter S A1 - Brown, Michael R A1 - Brody, Jennifer A A1 - Clarke, Toni-Kim A1 - Dimou, Niki A1 - Jessica Faul A1 - Homuth, Georg A1 - Jackson, Anne U A1 - Kentistou, Katherine A A1 - Joshi, Peter K A1 - Lemaitre, Rozenn N A1 - Penelope A Lind A1 - Lyytikäinen, Leo-Pekka A1 - Mangino, Massimo A1 - Milaneschi, Yuri A1 - Nelson, Christopher P A1 - Ilja M Nolte A1 - Perälä, Mia-Maria A1 - Polasek, Ozren A1 - David J Porteous A1 - Scott M Ratliff A1 - Smith, Jennifer A A1 - Stančáková, Alena A1 - Teumer, Alexander A1 - Tuominen, Samuli A1 - Thériault, Sébastien A1 - Vangipurapu, Jagadish A1 - Whitfield, John B A1 - Wood, Alexis A1 - Yao, Jie A1 - Yu, Bing A1 - Zhao, Wei A1 - Dan E Arking A1 - Auvinen, Juha A1 - Liu, Chunyu A1 - Männikkö, Minna A1 - Risch, Lorenz A1 - Rotter, Jerome I A1 - Snieder, Harold A1 - Veijola, Juha A1 - Alexandra I Blakemore A1 - Boehnke, Michael A1 - Campbell, Harry A1 - Conen, David A1 - Johan G Eriksson A1 - Hans-Jörgen Grabe A1 - Guo, Xiuqing A1 - van der Harst, Pim A1 - Catharina A Hartman A1 - Caroline Hayward A1 - Andrew C Heath A1 - Järvelin, Marjo-Riitta A1 - Kähönen, Mika A1 - Sharon L R Kardia A1 - Kühne, Michael A1 - Kuusisto, Johanna A1 - Laakso, Markku A1 - Lahti, Jari A1 - Lehtimäki, Terho A1 - McIntosh, Andrew M A1 - Mohlke, Karen L A1 - Alanna C Morrison A1 - Nicholas G Martin A1 - Oldehinkel, Albertine J A1 - Brenda W J H Penninx A1 - Psaty, Bruce M A1 - Olli T Raitakari A1 - Rudan, Igor A1 - Nilesh J Samani A1 - Scott, Laura J A1 - Timothy Spector A1 - Verweij, Niek A1 - David R Weir A1 - James F Wilson A1 - Levy, Daniel A1 - Tzoulaki, Ioanna A1 - Bell, Jimmy D A1 - Matthews, Paul M A1 - Rothenfluh, Adrian A1 - Desrivières, Sylvane A1 - Schumann, Gunter A1 - Elliott, Paul KW - Adult KW - Aged KW - Alcohol Drinking KW - Alcoholism KW - Brain KW - Female KW - genes KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Mental Disorders KW - Middle Aged KW - Neuroimaging KW - Polymorphism, Single Nucleotide KW - Quantitative Trait Loci KW - Schizophrenia KW - Whites AB -
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
VL - 3 IS - 9 ER -