TY - JOUR T1 - Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter? JF - Alzheimer's & Dementia Y1 - 2018 A1 - Jaimie C Hunter A1 - Elizabeth P. Handing A1 - Casanova, Ramon A1 - Kuchibhatla, Maragatha A1 - Michael W Lutz A1 - Saldana, Santiago A1 - Brenda L Plassman A1 - Kathleen M Hayden KW - Cognitive Ability KW - Neighborhoods KW - Sleep KW - Socioeconomic factors AB - Introduction We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. Methods Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multiple biennial cognitive observations (abbreviated Telephone Interview for Cognitive Status), were included. Participants were grouped into quartiles of NSES and sleep quality scores. We adjusted for apolipoprotein E ε4, demographic, and cardiovascular risk factors. Random effects modeling evaluated cognitive change over time. Results NSES and sleep were significantly associated with cognitive decline, and there was a significant interaction between them (P = .02). Significant differences between high/low NSES and high/low sleep quality (P < .0001) were found. Discussion Sleep and NSES were associated with cognitive decline; the association between sleep and cognition appeared stronger among those with low NSES. The association between low NSES, poor sleep quality, and cognitive decline was roughly equivalent to the association between apolipoprotein E ε4 and cognitive decline. VL - 14 UR - https://pubmed.ncbi.nlm.nih.gov/29396109/ IS - 4 JO - Alzheimer's & Dementia ER -