TY - JOUR T1 - Self-reported sense of purpose in life and proxy-reported behavioral and psychological symptoms of dementia in the last year of life. JF - Aging and Mental Health Y1 - 2022 A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Yannick Stephan A1 - Antonio Terracciano KW - Behavioral Symptoms KW - BPSD KW - Dementia KW - end of life KW - Purpose in life AB -

Behavioral and psychological symptoms of dementia (BPSD) are among the most challenging aspects of dementia for individuals living with dementia and their caregivers. Identifying factors associated with resilience to BPSD may inform interventions to reduce them. The present research examines whether purpose in life is associated with BPSD in the last year of life.Participants from the Health and Retirement Study were selected if they reported on their sense of purpose, had evidence of a memory impairment, died across the follow-up, and a proxy completed the End of Life survey that included BPSD ( = 2473). Self-reported sense of purpose was tested as a predictor of the sum of symptoms and each indivdual symptom in the last year of life.Purpose in life was associated with fewer BPSD overall. Of the individual symptoms, purpose was associated with less risk of psychological symptoms, specfiically less depression, periodic confusion, uncontrolled temper, but not with motor or perceptual symptoms. These results are consistent with growing evidence that purpose is associated with better cognitive outcomes. Purpose may be a useful target of intervention to improve outcomes across the spectrum of dementia.

VL - 26 IS - 8 ER - TY - JOUR T1 - Sense of Purpose in Life and Markers of Hearing Function: Replicated Associations across Two Longitudinal Cohorts. JF - Gerontology Y1 - 2022 A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Damaris Aschwanden A1 - Yannick Stephan A1 - Antonio Terracciano KW - Episodic Memory KW - hearing acuity KW - Hearing loss KW - Replication KW - Sense of purpose AB -

INTRODUCTION: A sense of purpose in life is a psychological resource that is associated with healthier outcomes. The present research examines whether a greater sense of purpose in life is associated with subjective and objective markers of hearing health and whether hearing acuity contributes to the association between purpose and episodic memory. We sought to evaluate whether these associations were replicable across 2 independent samples.

METHODS: Participants in the Health and Retirement Study (N = 14,291) and the English Longitudinal Study of Ageing (N = 8,844) reported on their purpose in life and perceived hearing quality at baseline. Hearing acuity was measured using an audiometer 2-4 years later, and episodic memory was measured at baseline and 6-8 years later.

RESULTS: In both samples, higher purpose in life was associated with better hearing quality measured concurrently, lower risk of either subjective or objective hearing impairment, and hearing acuity accounted for some of the longitudinal relation between sense of purpose and better episodic memory.

DISCUSSION: Across samples, measures, and analytical approaches, the present research indicates replicable associations between sense of purpose in life and hearing health. It further indicates that hearing may be one factor that associates purpose with better episodic memory.

VL - 68 IS - 8 ER - TY - JOUR T1 - Subjective Aging and Objectively Assessed Hearing Function: A Prospective Study of Older Adults. JF - The Journals of Gerontology, Series B Y1 - 2022 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Antonio Terracciano KW - hearing acuity KW - self-perceptions of aging KW - Subjective age AB -

OBJECTIVES: Subjective aging is consistently related to a range of health-related outcomes, but little is known about its relationship with sensory functioning. The present prospective study tested whether subjective age and self-perceptions of aging (SPA) are associated with objective hearing function.

METHOD: Participants were 7,085 individuals aged 50 to 93 years (60% women, Mean= 65.15, SD= 8.71) from the Health and Retirement Study (HRS). Measures of subjective age, SPA, and information on demographic factors were obtained in 2008/2010. Objective hearing function was assessed eight years later in 2016/2018. Furthermore, potential mediating variables (c-reactive protein, body mass index, physical inactivity, and chronic conditions) were assessed in 2012/2014.

RESULTS: In regression analyses that accounted for demographic factors, older subjective age and negative SPA were associated with lower hearing acuity eight years later. In addition, 1 SD older subjective age and negative SPA were related to a 9% and 7% higher likelihood of hearing impairment. Mediation analyses revealed that physical inactivity and chronic conditions partially mediated subjective age and SPA associations with hearing acuity. There was little evidence that the link between subjective aging and hearing was moderated by hearing aids and partial support for a moderating role of age.

CONCLUSION: This study provides new evidence that subjective aging is prospectively related to hearing function. Individuals with older subjective age or negative SPA have unfavorable behavioral and clinical profiles that explain part of their lower hearing function. Individuals' experience with their aging process is a marker of risk for impaired hearing.

VL - 77 IS - 9 ER - TY - JOUR T1 - Self-Rated Health and Incident Dementia over Two Decades: Replication Across Two Cohorts JF - Journal of Psychiatric Research Y1 - 2021 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Damaris Aschwanden A1 - Antonio Terracciano KW - Dementia KW - longitudinal KW - Risk Factors KW - Self-rated health AB - This prospective study examined the association between self-rated health and incident dementia in two large cohorts of middle-aged and older adults. Participants were drawn from the Health and Retirement Study (HRS, N= 13,839, Mean Age= 64.32, SD= 9.04) and the English Longitudinal Study of Ageing (ELSA, N=4649, Mean Age = 64.44, SD= 9.97). Self-rated health and covariates were assessed at baseline in 1998 and 2002, and cognitive status was tracked for up to 21 years in HRS and 17 years in ELSA, respectively. Controlling for demographic factors, poorer self-rated health was associated with higher risk of incident dementia in HRS (HR: 1.18, 95%CI: 1.12-1.24, p<.001) and ELSA (HR: 1.38, 95%CI: 1.23-1.55, p<.001). These associations remained significant when diabetes, hypertension, smoking, physical inactivity, depressive symptoms, personality, and polygenic risk for Alzheimer’s Disease were included as additional covariates or when cases occurring within the first ten years of follow-up were excluded from the analyses. There was no replicable evidence that age, sex, education, race or ethnicity moderated the association. Self-rated health is a long-term, replicable predictor of incident dementia that is independent of genetic, clinical, and behavioral risk factors. VL - 143 SN - 0022-3956 ER - TY - JOUR T1 - Subjective age and informant-rated cognition and function: A prospective study. JF - Psychology and Aging Y1 - 2021 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Antonio Terracciano KW - Cognition KW - HCAP KW - Subjective age AB -

The present study examined whether subjective age is related to informant-rated cognition. Participants were adults ( = 2,337, mean age = 69.84 years, = 7.45) from the Health and Retirement Study who provided subjective age and demographic factors in 2008/2010 and informant-rated cognition in 2016 as part of the Harmonized Cognitive Assessment Protocol. An older subjective age was associated with informant reports of steeper cognitive decline, worse cognitive function, lower ability, and loss of ability to do everyday activities. The present study indicates that subjective age predicts cognitive function in everyday life as observed by knowledgeable informants. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

VL - 36 IS - 3 ER - TY - JOUR T1 - Subjective age and multiple cognitive domains in two longitudinal samples JF - Journal of Psychosomatic Research Y1 - 2021 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Damaris Aschwanden A1 - Antonio Terracciano KW - Adulthood KW - Cognition KW - Executive function KW - Memory KW - numeric reasoning KW - Subjective age KW - verbal fluency KW - Visuospatial ability AB - Objective Subjective age is consistently related to memory performance and global cognitive function among older adults. The present study examines whether subjective age is prospectively related to specific domains of cognitive function. Method Participants were drawn from the Health and Retirement Study (HRS, N = 2549, Mean Age = 69.66, SD = 7.36) and the Midlife in the United States Survey (MIDUS, N = 2499, Mean Age = 46.24, SD = 11.25). In both samples, subjective age, depressive symptoms, chronic conditions, and demographic factors were assessed at baseline. Four domains of cognition were assessed 8 years later in the HRS and almost 20 years later in the MIDUS: episodic memory, speed-attention-executive, verbal fluency, and numeric reasoning. HRS also assessed visuospatial ability. Results Regression analysis revealed that an older subjective age was related to worse performance in the domains of episodic memory and speed-attention-executive in both samples. The effect size for the difference between a younger and an older subjective age was d = 0.14 (MIDUS) and d = 0.24 (HRS) for episodic memory and d = 0.25 (MIDUS) and d = 0.33 (HRS) for speed-attention-executive. Feeling older was related to lower verbal fluency in HRS (d = 0.30) but not in MIDUS, whereas no association was found with numeric reasoning in either sample. An older subjective age was related to lower visuospatial ability in HRS (d = 0.25). Conclusion Subjective age is prospectively related to performance in different cognitive domains. The associations between subjective age and both episodic memory and speed-attention-executive functions were replicable and robust over up to 20 years of follow-up. VL - 150 ER - TY - JOUR T1 - Subjective Age and Verbal Fluency among Middle Aged and Older Adults: A Meta-Analysis of Five Cohorts JF - Archives of Gerontology and Geriatrics Y1 - 2021 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Martina Luchetti A1 - Damaris Aschwanden A1 - Antonio Terracciano KW - Adulthood KW - ELSA KW - Sister studies KW - Subjective age KW - verbal fluency AB - Objectives This study aimed to examine the relation between subjective age and verbal fluency in five large samples of older adults to advance knowledge on the role of subjective age in a complex cognitive function that is an intermediate marker of cognitive impairment and dementia risk. Methods Participants (N > 27,000), aged 32 to 99 years old, predominantly white, were from the Wisconsin Longitudinal Study Graduate (WLSG) and Siblings (WLSS) samples, the Health and Retirement Study (HRS), the Midlife in the United States Study (MIDUS), and the English Longitudinal Study of Ageing (ELSA). They provided complete data on subjective age, demographic factors and verbal fluency. Estimates from each sample were combined in a meta-analysis. Results Across each of the five samples and in the meta-analysis, an older subjective age was related to lower performance on the verbal fluency task. This association was independent of chronological age and was not moderated by age, sex, nor education. The difference in fluency between individuals with an older and younger subjective age ranged from d= .09 to d= .37 across the five samples. Conclusions This study found replicable evidence for an association between an older subjective age and lower verbal fluency, extending knowledge about an intermediate marker of cognitive function. VL - 97 ER - TY - JOUR T1 - Subjective Aging and Incident Cardiovascular Disease. JF - The Journals of Gerontology: Series B Y1 - 2021 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Wurm, Susanne A1 - Antonio Terracciano KW - ardiovascular disease KW - self-perceptions of aging KW - Stroke KW - Subjective age AB -

OBJECTIVES: Subjective aging, including subjective age and self-perceptions of aging (SPA), predicts health-related outcomes in older adults. Despite its association with cardiovascular risk factors, little is known about the association between subjective aging and the incidence of cardiovascular disease. Therefore, the present study examined whether subjective age and SPA are related to the incidence of heart conditions and stroke.

METHODS: The sample comprises 10,695 participants aged 50-100 years from the Health and Retirement Study. Subjective age, SPA, demographic factors, and health-related behaviors, body mass index (BMI), hypertension, diabetes, and depressive symptoms were assessed at baseline. Self-reported physician diagnosis of heart conditions and stroke were assessed biennially over up to 9 years of follow-up.

RESULTS: Controlling for demographic factors, an older subjective age and more negative SPA were related to a higher risk of incident heart conditions and stroke. Feeling older and holding negative SPA were associated with around 40% higher risk of experiencing heart conditions over time. An older subjective age and negative SPA were related to almost twofold and 30% higher risk of incident stroke, respectively. Health risk behaviors, BMI, hypertension, diabetes, and depressive symptoms accounted for part of the associations between subjective aging and heart diseases and stroke.

CONCLUSIONS: Consistent with the literature on subjective aging and cardiovascular risk factors, this large prospective study indicates that an older subjective age and negative SPA increase the risk of incident stroke and other cardiovascular diseases.

VL - 76 IS - 5 ER - TY - JOUR T1 - Self-Reported Personality Traits and Informant-Rated Cognition: A 10-Year Prospective Study JF - Journal of Alzheimer's Disease Y1 - 2019 A1 - Angelina R Sutin A1 - Yannick Stephan A1 - Antonio Terracciano KW - Aged KW - agreeableness KW - Article KW - Cognition KW - Conscientiousness KW - extraversion KW - Female KW - follow up KW - human KW - major clinical study KW - Male KW - neurosis KW - openness KW - Personality KW - priority journal KW - prospective study KW - Self Report AB - Personality traits, such as higher Neuroticism and lower Conscientiousness, are associated with risk of Alzheimer's disease and other dementias. A diagnosis of dementia relies, in part, on informant ratings of the individual's cognitive status. Here we examine whether self-reported personality traits are associated with four measures of informant-rated cognition up to a decade later. Participants from the Health and Retirement Study (N = 2,536) completed a five-factor model measure of personality in 2006 or 2008. Informants completed the 2016 Harmonized Cognitive Assessment Protocol (HCAP), which included ratings of the participant's current cognitive functioning and change in cognitive function over the last decade assessed with the IQCODE, Blessed, 1066, and CSID. Controlling for characteristics of the participant, informant, and their relationship, higher Neuroticism and lower Conscientiousness were associated consistently with worse informant-rated cognition. The association between Openness and better informant-rated cognition was due primarily to higher baseline cognitive function. Extraversion and Agreeableness were associated with better informant-rated cognition only among participants who were cognitively intact at follow-up. The present research suggests that knowledgeable informants are able to detect cognitive deficits associated with personality. © 2019 - IOS Press and the authors. All rights reserved. VL - 72 UR - https://www.ncbi.nlm.nih.gov/pubmed/31561364 N1 - cited By 0 ER - TY - JOUR T1 - Subjective Age and Cystatin C Among Older Adults. JF - Journals of Gerontology, Series B: Psychological Sciences & Social Sciences Y1 - 2019 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Antonio Terracciano A1 - Shevaun Neupert KW - Cystatin C KW - Health Conditions and Status KW - Subjective age AB -

Objective: Cystatin C (CysC) is a marker of kidney function that is relevant for the health and cognition of older adults. Little is known about the link between psychological factors and CysC. Therefore, the present study examined whether subjective age is related to CysC level and changes in CysC over time.

Method: Participants were 5,066 individuals drawn from the Health and Retirement Study aged from 50 to 107 years (60% women, mean age = 69.36 years, SD = 9.54). They provided data on subjective age, demographic covariates, and CysC at baseline. CysC was assessed again 4 years later.

Results: Analysis revealed that an older subjective age was related to higher level of CysC at baseline and to an increase in CysC over 4 years, controlling for demographic factors. An older subjective age was also related to higher risk of exceeding the clinical threshold of CysC at baseline and 4 years later. Additional analysis revealed that disease burden, depressive symptoms, physical inactivity, and BMI partly mediated these associations.

Conclusion: The present study provides new evidence on the role of subjective age as a psychological factor associated with individuals' risk of kidney dysfunction, an association beyond chronological age.

VL - 74 IS - 3 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29045722?dopt=Abstract ER - TY - JOUR T1 - Self-reported personality traits are prospectively associated with proxy-reported behavioral and psychological symptoms of dementia at the end of life. JF - International Journal of Geriatric Psychiatry Y1 - 2018 A1 - Angelina R Sutin A1 - Yannick Stephan A1 - Martina Luchetti A1 - Antonio Terracciano KW - Cognitive Ability KW - Dementia KW - Personality KW - Self-reported health AB -

OBJECTIVE: Behavioral and psychological symptoms of dementia (BPSD) are among the most challenging aspects of Alzheimer disease for patients and their families. Previous studies have found associations between informant-reported retrospective personality and BPSD; we test whether prospective, self-reported personality predicts who will experience these symptoms.

METHODS: Deceased participants from the Health and Retirement Study who had evidence of cognitive impairment at the end of life (N = 1988) were selected to examine whether self-reported five-factor model personality traits, measured up to 8 years before death, were associated with proxy-reported BPSD.

RESULTS: Neuroticism was associated with increased risk of the 7 BPSD: got lost in familiar places, wandered off, were not able to be left alone, experienced hallucinations, suffered from depression, had periodic confusion, and an uncontrolled temper. These associations were not moderated by age, gender, race, or education. Conscientiousness was associated with fewer symptoms overall and especially with lower risk of getting lost in familiar places and not being able to be left alone.

CONCLUSIONS: The present research indicates that self-reported personality, particularly Neuroticism, is associated prospectively with risk for a wide range of behavioral symptoms for individuals who had cognitive impairment at the end of life. The use of self-reported personality traits can help aid in identifying who is most at risk for behavioral symptoms. Such information may be useful for nonpharmacological interventions tailored to the individual's personality to reduce the prevalence and burden of these BPSD.

VL - 33 IS - 3 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28869657?dopt=Abstract ER - TY - JOUR T1 - Subjective Age and Mortality in Three Longitudinal Samples. JF - Psychosomatic Medicine Y1 - 2018 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Antonio Terracciano KW - Mortality KW - Subjective age KW - Subjective Expectations AB -

OBJECTIVE: Subjective age has been implicated in a range of health outcomes. The present study extends existing research by providing new data on the relation between subjective age and mortality in three large national samples.

METHODS: Participants (total N > 17,000) were drawn from the Health and Retirement Study (HRS, 2008-2014), the Midlife in the United State Survey (MIDUS, 1995-2014), and the National Health and Aging Trends Study (NHATS, 2011-2014). Subjective age, demographic factors, disease burden, functional limitations, depressive symptoms, and physical inactivity were assessed at baseline and mortality data were tracked for up to 20 years. Cognition was also included as a covariate in the HRS and the NHATS.

RESULTS: Individuals felt on average 15% to 16% younger relative to their chronological age. Feeling approximately 8, 11, and 13 years older in the MIDUS, HRS, and NHATS, was related to an 18%, 29% and 25% higher risk of mortality, respectively. This pattern was confirmed by a meta-analysis of the three samples (HR = 1.24; 95%CI = 1.17-1.31, p<.001). Multivariate analyses showed that disease burden, physical inactivity, functional limitations, and cognitive problems, but not depressive symptoms, accounted for the associations between subjective age and mortality.

CONCLUSIONS: The present study provides robust evidence for an association between an older subjective age and a higher risk of mortality across adulthood. These findings support the role of subjective age as a biopsychosocial marker of aging.

VL - 80 IS - 7 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29864106?dopt=Abstract ER - TY - JOUR T1 - Sensory functioning and personality development among older adults. JF - Psychology and Aging Y1 - 2017 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Bosselut, Grégoire A1 - Antonio Terracciano KW - Older Adults KW - Personality AB - Deficits in sensory functioning, such as poor vision and hearing, take a significant toll on quality of life. Little is known, however, about their relation with personality development across adulthood. This study examined whether baseline and change in vision and hearing were associated with personality change over a 4-year period. Participants (N = 7,471; Mage = 66.89; 59% women) were drawn from the Health and Retirement Study. They provided data on vision, hearing, and personality both at baseline and 4 years later. Poor vision and hearing at baseline and declines in vision and hearing over time were independently related to steeper declines in extraversion, agreeableness, openness, and conscientiousness, and less decline in neuroticism, controlling for demographic factors, disease burden, and depressive symptoms. Sensory functioning was generally a stronger predictor of personality change than disease burden or depressive symptoms. Consistent with evidence that poor and worsening sensory functions compromise individuals' interactions with the social and physical environment, this study found deficits in hearing and vision were also associated with maladaptive personality trajectories in older adults. VL - 32 IS - 2 ER - TY - JOUR T1 - Subjective age and sleep in middle-aged and older adults. JF - Psychology & Health Y1 - 2017 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Bayard, Sophie A1 - Antonio Terracciano KW - Anxiety KW - Depressive symptoms KW - Sleep AB -

OBJECTIVE: Chronological age is commonly used to explain change in sleep. The present study examines whether subjective age is associated with change in sleep difficulties across middle adulthood and old age.

DESIGN: Participants were drawn from the second (2004-2005) and third (2013-2014) waves of the Midlife in the United States Survey (MIDUS, N = 2350; Mean Age: 55.54 years), the 2008 and 2014 waves of the Health and Retirement Study (HRS, N = 4066; Mean Age: 67.59 years) and the first (2011) and fourth (2014) waves of the National Health and Aging Trends Survey (NHATS, N = 3541; Mean Age: 76.46). In each sample, subjective age, sleep difficulties, depressive symptoms, anxiety and chronic conditions were assessed at baseline. Sleep difficulties was assessed again at follow-up.

MAIN OUTCOME MEASURES: Sleep difficulties.

RESULTS: An older subjective age at baseline was related to an increase in sleep difficulties over time in the three samples, and was mediated, in part, through more depressive symptoms, anxiety and chronic conditions. Feeling older was associated with an increased likelihood of major sleeping difficulties at follow-up in the three samples.

CONCLUSION: Subjective age is a salient marker of individuals' at risk for poor sleep quality, beyond chronological age.

VL - 32 IS - 9 U1 - http://www.ncbi.nlm.nih.gov/pubmed/28480746?dopt=Abstract ER - TY - JOUR T1 - Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. JF - Psychol Med Y1 - 2016 A1 - Demirkan, A A1 - J. Lahti A1 - Nese Direk A1 - Viktorin, A. A1 - Kathryn L Lunetta A1 - Antonio Terracciano A1 - Michael A Nalls A1 - Toshiko Tanaka A1 - Karin Hek A1 - Myriam Fornage A1 - Jürgen Wellmann A1 - Marilyn C Cornelis A1 - Ollila, H. M. A1 - Lei Yu A1 - Luke C Pilling A1 - Isaacs, A A1 - Aarno Palotie A1 - Wei Vivian Zhuang A1 - Alan B Zonderman A1 - Jessica Faul A1 - Angelina R Sutin A1 - Osorio Meirelles A1 - Mulas, A A1 - Hofman, A A1 - André G Uitterlinden A1 - Fernando Rivadeneira A1 - Markus Perola A1 - Wei Zhao A1 - Veikko Salomaa A1 - Kristine Yaffe A1 - Luik, A I A1 - Yongmei Liu A1 - Ding, J A1 - Paul Lichtenstein A1 - Landén, M A1 - Elisabeth Widen A1 - David R Weir A1 - David J Llewellyn A1 - Murray, A A1 - Sharon L R Kardia A1 - Johan G Eriksson A1 - Karestan C Koenen A1 - Patrik K E Magnusson A1 - Luigi Ferrucci A1 - Thomas H Mosley A1 - Francesco Cucca A1 - Ben A Oostra A1 - David A Bennett A1 - Paunio, T. A1 - Klaus Berger A1 - Tamara B Harris A1 - Nancy L Pedersen A1 - Joanne M Murabito A1 - Henning Tiemeier A1 - Cornelia M van Duijn A1 - Katri Räikkönen KW - depression KW - Depressive Disorder, Major KW - Genome-Wide Association Study KW - Humans KW - Polymorphism, Single Nucleotide KW - Receptor, Melatonin, MT1 KW - Somatoform Disorders AB -

BACKGROUND: Major depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD may be hindered by heterogeneity in diagnosis. The Center for Epidemiological Studies Depression (CES-D) scale provides a widely used tool for measuring depressive symptoms clustered in four different domains which can be combined together into a total score but also can be analysed as separate symptom domains.

METHOD: We performed a meta-analysis of GWAS of the CES-D symptom clusters. We recruited 12 cohorts with the 20- or 10-item CES-D scale (32 528 persons).

RESULTS: One single nucleotide polymorphism (SNP), rs713224, located near the brain-expressed melatonin receptor (MTNR1A) gene, was associated with the somatic complaints domain of depression symptoms, with borderline genome-wide significance (p discovery = 3.82 × 10-8). The SNP was analysed in an additional five cohorts comprising the replication sample (6813 persons). However, the association was not consistent among the replication sample (p discovery+replication = 1.10 × 10-6) with evidence of heterogeneity.

CONCLUSIONS: Despite the effort to harmonize the phenotypes across cohorts and participants, our study is still underpowered to detect consistent association for depression, even by means of symptom classification. On the contrary, the SNP-based heritability and co-heritability estimation results suggest that a very minor part of the variation could be captured by GWAS, explaining the reason of sparse findings.

VL - 46 UR - https://www.ncbi.nlm.nih.gov/pubmed/26997408 IS - 8 U1 - http://www.ncbi.nlm.nih.gov/pubmed/26997408?dopt=Abstract ER - TY - JOUR T1 - Subjective Age and Changes in Memory in Older Adults JF - The Journals of Gerontology Series B: Psychological Sciences and Social Sciences Y1 - 2016 A1 - Yannick Stephan A1 - Angelina R Sutin A1 - Caudroit, Johan A1 - Antonio Terracciano KW - Expectations KW - Health Conditions and Status AB - Objective. The subjective experience of aging, indexed by how old or young an individual feels, has been related to well-being and health-related outcomes among older adults. The present study examined whether subjective age is associated with memory level and changes, as indexed by measures of immediate and delayed recall. A complementary purpose was to test the mediating role of depressive symptoms and physical activity in the relation between subjective age and memory changes. Method. Participants were drawn from three waves of the Health and Retirement Study. Subjective age, baseline memory measures, and covariates were assessed during the 2008 wave (N = 5809), depressive symptoms and physical activity were assessed again in the 2010 wave, and the follow-up memory measures were assessed in the 2012 wave. Results. Regression analyses that included demographic, metabolic, and vascular covariates revealed that a younger subjective age at baseline was associated with better concurrent performance and with slower decline in immediate and delayed recall. Bootstrap procedures indicated that fewer depressive symptoms mediated these associations. Additional analyses revealed that memory level and change were unrelated to changes in subjective age. Conclusion. Beyond chronological age, the subjective experience of age is associated with cognitive aging. VL - 71 UR - http://psychsocgerontology.oxfordjournals.org/content/early/2015/03/05/geronb.gbv010.abstract IS - 4 U4 - depression/Depressive Symptoms/memory/physical activity/subjective age/Cognition ER - TY - JOUR T1 - Spouses and depressive symptoms in older adulthood. JF - Sci Rep Y1 - 2015 A1 - Pradeep, Neeti A1 - Angelina R Sutin KW - Aged KW - depression KW - Female KW - Humans KW - Longitudinal Studies KW - Male KW - Sex Distribution KW - Spouses AB -

Depressive symptoms may co-occur within couples and follow similar trajectories, but relatively little is known about this process in old age. This study thus examined the association between some spousal characteristics (spouse's depressive symptoms, age difference between spouses) and the trajectory of depressive symptoms in older adults. Participants ≥ 65 years old were drawn from the Health and Retirement Study (N = 12,010; Mean age = 70.60 and 69.16 for target husbands and wives, respectively). Depressive symptoms were measured with a short form of the Center for Epidemiological Studies Depression (CES-D) scale. Hierarchical Linear Modeling was used to model up to 9 assessments of depressive symptoms of target spouses (Mean number of CESD assessments per target spouse = 3, range 1-9). Depressive symptoms between spouses were correlated; convergence over time was modest. For both husbands and wives, having a younger spouse was associated with more depressive symptoms at age 65. These results suggest that there is concordance between spouses' depressive symptoms and that the age difference between spouses contribute to depressive symptoms as couples enter old age. The association between spouses' depressive symptoms is nearly as strong as the effect of each decade increase in age.

PB - 5 VL - 5 N1 - Times Cited: 0 0 U1 - http://www.ncbi.nlm.nih.gov/pubmed/25716455?dopt=Abstract U2 - PMC4341217 U4 - Depressive Symptoms/depression/spousal characteristics/Trajectories/Hierarchical Linear Modeling ER -