%0 Journal Article %J Global Epidemiology %D 2020 %T The role of Hope in subsequent health and well-being for older adults: An outcome-wide longitudinal approach %A Long, Katelyn N.G. %A Eric S Kim %A Chen, Ying %A Wilson, Matthew F. %A Worthington Jr., Everett L. %A Tyler J VanderWeele %K Hope %K hopelessness %K Older Adults %K outcome-wide analysis %K Physical Health %K Well-being %X Hope is a topic widely discussed in the humanities and researched in the field of psychology. To explore the potential public health implications of hope for subsequent health and well-being outcomes, we prospectively examined the relation between baseline hope and a wide range of outcomes that included indicators of: physical health, health behaviors, and psychosocial well-being in older adults using an outcome-wide approach. Data from the Health and Retirement Study (N = 12,998, mean age = 66 years) were analyzed. Bonferroni correction was used to account for multiple testing. All models controlled for a wide array of factors including: sociodemographic characteristics, personality factors, and prior values of the exposure (hope) and all outcomes. A greater sense of hope was associated with: better physical health and health behavior outcomes on some indicators (e.g., reduced risk of all cause-mortality, fewer number of chronic conditions, lower risk of cancer, and fewer sleep problems), higher psychological well-being (e.g., increased positive affect, life satisfaction, and purpose in life), lower psychological distress, and better social well-being. A secondary analysis explored antecedents of hope. We identified several potentially modifiable factors that may lead to increased hope. These results may have important population-level implications for increasing hope and improving the physical, psychological, and social well-being of our growing older adult population. %B Global Epidemiology %V 2 %P 100018 %G eng %R https://doi.org/10.1016/j.gloepi.2020.100018