%0 Journal Article %J Biodemography Soc Biol %D 2014 %T A polygenic risk score associated with measures of depressive symptoms among older adults. %A Morgan E. Levine %A Eileen M. Crimmins %A Carol A Prescott %A Drystan F. Phillips %A Thalida E. Arpawong %A Jinkook Lee %K Aged %K Aged, 80 and over %K Depressive Disorder, Major %K Female %K Genetic Predisposition to Disease %K Genetic Variation %K Genome-Wide Association Study %K Humans %K Male %K Middle Aged %K Multifactorial Inheritance %K Odds Ratio %K Risk Factors %X

It has been suggested that depression is a polygenic trait, arising from the influences of multiple loci with small individual effects. The aim of this study is to generate a polygenic risk score (PRS) to examine the association between genetic variation and depressive symptoms. Our analytic sample included N = 10,091 participants aged 50 and older from the Health and Retirement Study (HRS). Depressive symptoms were measured by Center for Epidemiological Studies-Depression scale (CESD) scores assessed on up to nine occasions across 18 years. We conducted a genome-wide association analysis for a discovery set (n = 7,000) and used the top 11 single-nucleotide polymorphisms, all with p < 10(-5) to generate a weighted PRS for our replication sample (n = 3,091). Results showed that the PRS was significantly associated with mean CESD score in the replication sample (β = .08, p = .002). The R(2) change for the inclusion of the PRS was .003. Using a multinomial logistic regression model, we also examined the association between genetic risk and chronicity of high (4+) CESD scores. We found that a one-standard-deviation increase in PRS was associated with a 36 percent increase in the odds of having chronically high CESD scores relative to never having had high CESD scores. Our findings are consistent with depression being a polygenic trait and suggest that the cumulative influence of multiple variants increases an individual's susceptibility for chronically experiencing high levels of depressive symptoms.

%B Biodemography Soc Biol %I 60 %V 60 %P 199-211 %8 2014 %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/25343367?dopt=Abstract %2 PMC4298361 %4 GENOME-WIDE ASSOCIATION/INDIVIDUAL GENETIC RISK/MAJOR DEPRESSION/DISEASE RISK/HERITABILITY/genetics/genetics/depression/Depressive Symptoms/CES Depression Scale/CES Depression Scale/regression Analysis %$ 999999 %R 10.1080/19485565.2014.952705