%0 Journal Article %J Am J Obstet Gynecol %D 2009 %T Major depression and urinary incontinence in women: temporal associations in an epidemiologic sample. %A Jennifer L Melville %A Fan, Ming-Yu %A Rau, Holly %A Ingrid E Nygaard %A Wayne J Katon %K Depressive Disorder, Major %K Female %K Humans %K Longitudinal Studies %K Middle Aged %K Risk Factors %K Time Factors %K Urinary incontinence %X

OBJECTIVE: To determine whether: (1) major depression is associated with increased risk for onset of urinary incontinence, and (2) urinary incontinence is associated with increased risk for onset of depression.

STUDY DESIGN: Longitudinal cohort study of female Health and Retirement Study participants completing baseline interviews at Wave 3 (1996-1997) and follow-up interviews at Waves 4-6 (1998-2003).

RESULTS: In a cohort of 5820 women with a mean age 59.3 (+/- 0.5) years, 6-year cumulative incidences of depression and incontinence were 11% and 21%, respectively. Major depression was associated with increased odds of incident incontinence (adjusted odds ratio, 1.46; 95% confidence interval, 1.08-1.97) during follow-up compared with those without major depression at baseline. Conversely, incontinence was not associated with increased odds of incident depression (adjusted odds ratio, 1.03; 95% confidence interval, 0.75-1.42) compared with those without incontinence at baseline.

CONCLUSION: Major depression predicted onset of urinary incontinence in a population-based sample of at-risk, community-dwelling women. Incontinence did not predict onset of depression.

%B Am J Obstet Gynecol %I 201 %V 201 %P 490.e1-7 %8 2009 Nov %G eng %N 5 %L newpubs20091202_Melville.pdf %1 http://www.ncbi.nlm.nih.gov/pubmed/19716547?dopt=Abstract %3 19716547 %4 Depression/Women/Incontinence %$ 21320 %R 10.1016/j.ajog.2009.05.047