%0 Journal Article %J Alzheimers Res Ther %D 2010 %T Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. %A David J Llewellyn %A Iain A Lang %A Fiona E Matthews %A Brenda L Plassman %A Mary A M Rogers %A Lewis B Morgenstern %A Gwenith G Fisher %A Mohammed U Kabeto %A Kenneth M. Langa %X

INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia.

METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression.

RESULTS: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001).

CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia.

%B Alzheimers Res Ther %I 2 %V 2 %P 19 %8 2010 Jun 24 %G eng %U http://alzres.com/content/2/3/19 %N 3 %L newpubs20110418_Llewellyn.pdf %1 http://www.ncbi.nlm.nih.gov/pubmed/20576093?dopt=Abstract %2 PMC2919699 %4 Dementia/Vascular dementia/Stroke %$ 24880 %R 10.1186/alzrt43