%0 Journal Article %J Diabetes Care %D 2013 %T Physical Function Limitations Among Middle-Aged and Older Adults With Prediabetes One exercise prescription may not fit all %A Pearl G. Lee %A Christine T Cigolle %A Ha, Jinkyung %A Lillian C. Min %A Susan L Murphy %A Caroline S Blaum %A Herman, William H. %K Demographics %K Disabilities %K Event History/Life Cycle %K Health Conditions and Status %K Other %K Risk Taking %X OBJECTIVETo describe the prevalence of physical function limitations among a nationally representative sample of adults with prediabetes.RESEARCH DESIGN AND METHODSWe performed a cross-sectional analysis of 5,991 respondents 53 years of age from the 2006 wave of the Health and Retirement Study. All respondents self-reported physical function limitations and comorbidities (chronic diseases and geriatric conditions). Respondents with prediabetes reported no diabetes and had a measured glycosylated hemoglobin (HbA(1c)) of 5.7-6.4 . Descriptive analyses and logistic regressions were used to compare respondents with prediabetes versus diabetes (diabetes history or HbA(1c) 6.5 ) or normoglycemia (no diabetes history and HbA(1c) 5.7 ).RESULTSTwenty-eight percent of respondents 53 years of age had prediabetes; 32 had mobility limitations (walking several blocks and/or climbing a flight of stairs); 56 had lower-extremity limitations (getting up from a chair and/or stooping, kneeling, or crouching); and 33 had upper-extremity limitations (pushing or pulling heavy objects and/or lifting 10 lb). Respondents with diabetes had the highest prevalence of comorbidities and physical function limitations, followed by those with prediabetes, and then normoglycemia (P 0.05). Compared with respondents with normoglycemia, respondents with prediabetes had a higher odds of having functional limitations that affected mobility (odds ratio OR 1.48), the lower extremities (OR 1.35), and the upper extremities (OR 1.37) (all P 0.01). The higher odds of having lower-extremity limitations remained after adjusting for age, sex, and body mass index (OR 1.21, P 0.05).CONCLUSIONSComorbidities and physical function limitations are prevalent among middle-aged and older adults with prediabetes. Effective lifestyle interventions to prevent diabetes must accommodate physical function limitations. %B Diabetes Care %I 36 %V 36 %P 3076-3083 %G eng %N 10 %4 Impaired Glucose Tolerance/Geriatric Conditions/United-States/Life Style/Disability/Disability/Health/Prevalence/Reduction/Risk Factor %$ 999999 %R 10.2337/dc13-0412