%0 Journal Article %J Neuroepidemiology %D 2005 %T The Aging, Demographics and Memory Study: Study Design and Methods %A Kenneth M. Langa %A Brenda L Plassman %A Robert B Wallace %A A. Regula Herzog %A Steven G Heeringa %A Mary Beth Ofstedal %A James F. Burke %A Gwenith G Fisher %A Fultz, Nancy H. %A Michael D Hurd %A Guy G Potter %A Willard L Rodgers %A David C Steffens %A David R Weir %K Health Conditions and Status %K Healthcare %X Objective: We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and cognitive impairment, not demented (CIND) using a unique study design based on the nationally representative Health and Retirement Study (HRS). We also illustrate potential uses of the ADAMS data and provide information to interested researchers on obtaining ADAMS and HRS data. Methods: The ADAMS is the first population-based study of dementia in the United States to include subjects from all regions of the country, while at the same time using a single standardized diagnostic protocol in a community-based sample. A sample of 856 individuals aged 70 or older who were participants in the on-going HRS received an extensive in-home clinical and neuropsychological assessment to determine a diagnosis of normal, CIND, or dementia. Within the CIND and dementia categories, subcategories (e.g., Alzheimer disease, vascular dementia) were assigned to denote the etiology of cognitive impairment. Conclusion: Linking the ADAMS dementia clinical assessment data to the wealth of available longitudinal HRS data on health, health care utilization, informal care, and economic resources and behavior, will provide a unique opportunity to study the onset of CIND and dementia in a nationally-representative population-based sample, as well as the risk factors, prevalence, outcomes, and costs of CIND and dementia. %B Neuroepidemiology %I 25 %V 25 %P 181-191 %G eng %L pubs_2005_Neuroepidemiology.pdf %4 Aging/Dementia/Epidemiology %$ 13302 %0 Journal Article %J J Aging Health %D 2003 %T Additive and interactive effects of comorbid physical and mental conditions on functional health. %A Fultz, Nancy H. %A Mary Beth Ofstedal %A A. Regula Herzog %A Robert B Wallace %K Activities of Daily Living %K Aged %K Aging %K Black or African American %K Cognition Disorders %K depression %K Diabetes Complications %K Educational Status %K Health Surveys %K Hispanic or Latino %K Humans %K Stroke %K United States %K White People %X

OBJECTIVE: To understand the role of cognitive impairment and depressive symptoms on functional outcomes of stroke and diabetes. Evaluation approaches to functional outcomes have rarely focused on the presence of specific comorbidities, particularly those involving mental health disorders.

METHODS: Data are from the AHEAD cohort of the Health and Retirement Study (HRS), a nationally representative panel of persons 70+ years of age in 1993. Analyses are limited to 5,646 self-respondents for whom functional outcome data are available in 1995. Additive and interactive multiple regression models are compared for each outcome and focal condition combination.

RESULTS: The additive model is sufficient for the majority of outcome and focal condition combinations. The interaction term is significant in 4 of 12 comparisons.

DISCUSSION: Stroke, diabetes, cognitive impairment, and depressive symptoms exhibit strong independent effects on physical functioning. Support for the hypothesis that cognitive impairment and depression exacerbate the impact of stroke and diabetes is more limited.

%B J Aging Health %I 15 %V 15 %P 465-81 %8 2003 Aug %G eng %N 3 %L pubs_2003_Fultz_etal.pdf %1 http://www.ncbi.nlm.nih.gov/pubmed/12914014?dopt=Abstract %4 Activities of Daily Living/Chronic Disease/Epidemiology/Health Surveys %$ 11682 %R 10.1177/0898264303253502