Genetic Data Consortia

HRS participates in a number of genetic data consortia. The published results of these collaborations are listed below, with links to the HRS Bibliography. Several projects are still in progress, and will be added to this page upon publication.

CHARGE

Cohorts for Heart and Aging Research in Genetic Epidemiology

Website: http://www.chargeconsortium.com/

Publications from the HRS Bibliography

Barban N, Jansen R, de Vlaming R, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016;48(12):1462-1472. doi:10.1038/ng.3698.
http://www.ncbi.nlm.nih.gov/pubmed/27798627?dopt=Abstract
Bihlmeyer NA, Brody JA, Smith AVernon, et al. Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159. doi:10.1186/s12863-014-0159-7.
http://www.ncbi.nlm.nih.gov/pubmed/25543667?dopt=Abstract
Broer L, Buchman AS, Deelen J, et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015;70(1):110-8. doi:10.1093/gerona/glu166.
http://www.ncbi.nlm.nih.gov/pubmed/25199915?dopt=Abstract
Davies G, Armstrong N, Joshua C. Bis, Ibrahim-Verbaas CA, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015;20(2):183-92. doi:10.1038/mp.2014.188.
http://www.ncbi.nlm.nih.gov/pubmed/25644384?dopt=Abstract
Demirkan A, Lahti J, Direk N, et al. Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med. 2016;46(8):1613-23. doi:10.1017/S0033291715002081.
http://www.ncbi.nlm.nih.gov/pubmed/26997408?dopt=Abstract
Liu C, Kraja AT, Smith JA, Morrison AC, et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016;48(10):1162-70. doi:10.1038/ng.3660.
Marouli E, Graff M, Medina-Gomez C, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017;542(7640):186-190. doi:10.1038/nature21039.
http://www.ncbi.nlm.nih.gov/pubmed/28146470?dopt=Abstract
Matteini AM, Tanaka T, Karasik D, et al. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016;15(5):792-800. doi:10.1111/acel.12468.
http://www.ncbi.nlm.nih.gov/pubmed/27325353?dopt=Abstract
Okbay A, Baselmans BML, De Neve J-E, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624-33. doi:10.1038/ng.3552.
http://www.ncbi.nlm.nih.gov/pubmed/27089181?dopt=Abstract
Pattaro C, Teumer A, Gorski M, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016;7:10023. doi:10.1038/ncomms10023.
http://www.ncbi.nlm.nih.gov/pubmed/26831199?dopt=Abstract
Rietveld CA, Medland SE, Derringer J, et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013;340(6139):1467-71. doi:10.1126/science.1235488.
http://www.ncbi.nlm.nih.gov/pubmed/23722424?dopt=Abstract

COGENT

Continental Origins and Genetic Epidemiology Network

Publications from the HRS Bibliography

Franceschini N, Fox E, Zhang Z, et al. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet. 2013;93(3):545-54. doi:10.1016/j.ajhg.2013.07.010.
http://www.ncbi.nlm.nih.gov/pubmed/23972371?dopt=Abstract

GIANT

Genetic Investigation of Anthropometric Traits

Website: http://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_co...

Publications from the HRS Bibliography

Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-206. doi:10.1038/nature14177.
http://www.ncbi.nlm.nih.gov/pubmed/25673413?dopt=Abstract
Turcot V, Lu Y, Highland HM, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50(1):26-41. doi:10.1038/s41588-017-0011-x.
http://www.ncbi.nlm.nih.gov/pubmed/29273807?dopt=Abstract
Yengo L, Sidorenko J, Kemper KE, et al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Human Molecular Genetics. 2018;27(20):3641-3649. doi:10.1093/hmg/ddy271.
http://www.ncbi.nlm.nih.gov/pubmed/30124842?dopt=Abstract

GLGC

Global Lipids Genetics Consortium

Website: http://www.kathiresanlab.org/collaborators/global-lipids-genetic-consort...

Analysis/publication in progress.

GSCAN

GWAS and Sequencing Consortium of Alcohol and Nicotine use

Website: https://gscan.sph.umich.edu/

Analysis/publication in progress.

MAGIC

Meta-Analyses of Glucose and Insulin-related traits Consortium

Website: https://www.magicinvestigators.org/

Analysis/publication in progress.

ReproGen

Reproductive Genetics Consortium

Website: http://www.reprogen.org/

Publications from the HRS Bibliography

Day FR, Ruth KS, Thompson DJ, et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet. 2015;47(11):1294-303. doi:10.1038/ng.3412.
http://www.ncbi.nlm.nih.gov/pubmed/26414677?dopt=Abstract

ROHGen

Runs of Homozygosity Genetics Consortium

Publications from the HRS Bibliography

Joshi PK, Esko T, Mattsson H, et al. Directional dominance on stature and cognition in diverse human populations. Nature. 2015;523(7561):459-62. doi:10.1038/nature14618.
http://www.ncbi.nlm.nih.gov/pubmed/26131930?dopt=Abstract

SiGN

Stroke Genetics Network

Publications from the HRS Bibliography

Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurology. 2016;15(2):174-184. doi:10.1016/S1474-4422(15)00338-5.

SSGAC

Social Science Genetics Association Consortium

Website: http://www.thessgac.org/

Publications from the HRS Bibliography

Okbay A, Beauchamp JP, Fontana MAlan, et al. Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 2016;533(7604):539-42. doi:10.1038/nature17671.
http://www.ncbi.nlm.nih.gov/pubmed/27225129?dopt=Abstract
Weiss A, Baselmans BML, Hofer E, et al. Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet. 2016;19(5):407-17. doi:10.1017/thg.2016.65.