HRS participates in a number of genetic data consortia. The published results of these collaborations are listed below, with links to the HRS Bibliography. Several projects are still in progress, and will be added to this page upon publication.
Genetic Data Consortia
CHARGE
Cohorts for Heart and Aging Research in Genetic Epidemiology
Website: http://www.chargeconsortium.com/
Publications from the HRS Bibliography
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016;48(12):1462-1472. doi:10.1038/ng.3698.
http://www.ncbi.nlm.nih.gov/pubmed/27798627?dopt=Abstract
Genetic diversity is a predictor of mortality in humans. BMC Genet. 2014;15:159. doi:10.1186/s12863-014-0159-7.
http://www.ncbi.nlm.nih.gov/pubmed/25543667?dopt=Abstract
GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015;70(1):110-8. doi:10.1093/gerona/glu166.
http://www.ncbi.nlm.nih.gov/pubmed/25199915?dopt=Abstract
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015;20(2):183-92. doi:10.1038/mp.2014.188.
http://www.ncbi.nlm.nih.gov/pubmed/25644384?dopt=Abstract
Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Psychol Med. 2016;46(8):1613-23. doi:10.1017/S0033291715002081.
http://www.ncbi.nlm.nih.gov/pubmed/26997408?dopt=Abstract
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016;48(10):1162-70. doi:10.1038/ng.3660.
Rare and low-frequency coding variants alter human adult height. Nature. 2017;542(7640):186-190. doi:10.1038/nature21039.
http://www.ncbi.nlm.nih.gov/pubmed/28146470?dopt=Abstract
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016;15(5):792-800. doi:10.1111/acel.12468.
http://www.ncbi.nlm.nih.gov/pubmed/27325353?dopt=Abstract
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624-33. doi:10.1038/ng.3552.
http://www.ncbi.nlm.nih.gov/pubmed/27089181?dopt=Abstract
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016;7:10023. doi:10.1038/ncomms10023.
http://www.ncbi.nlm.nih.gov/pubmed/26831199?dopt=Abstract
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013;340(6139):1467-71. doi:10.1126/science.1235488.
http://www.ncbi.nlm.nih.gov/pubmed/23722424?dopt=Abstract
COGENT
Continental Origins and Genetic Epidemiology Network
Publications from the HRS Bibliography
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet. 2013;93(3):545-54. doi:10.1016/j.ajhg.2013.07.010.
http://www.ncbi.nlm.nih.gov/pubmed/23972371?dopt=Abstract
GIANT
Genetic Investigation of Anthropometric Traits
Website: http://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_co...
Publications from the HRS Bibliography
Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-206. doi:10.1038/nature14177.
http://www.ncbi.nlm.nih.gov/pubmed/25673413?dopt=Abstract
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50(1):26-41. doi:10.1038/s41588-017-0011-x.
http://www.ncbi.nlm.nih.gov/pubmed/29273807?dopt=Abstract
Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Human Molecular Genetics. 2018;27(20):3641-3649. doi:10.1093/hmg/ddy271.
http://www.ncbi.nlm.nih.gov/pubmed/30124842?dopt=Abstract
ReproGen
Reproductive Genetics Consortium
Website: http://www.reprogen.org/
Publications from the HRS Bibliography
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet. 2015;47(11):1294-303. doi:10.1038/ng.3412.
http://www.ncbi.nlm.nih.gov/pubmed/26414677?dopt=Abstract
ROHGen
Runs of Homozygosity Genetics Consortium
Publications from the HRS Bibliography
Directional dominance on stature and cognition in diverse human populations. Nature. 2015;523(7561):459-62. doi:10.1038/nature14618.
http://www.ncbi.nlm.nih.gov/pubmed/26131930?dopt=Abstract
SiGN
Stroke Genetics Network
Publications from the HRS Bibliography
Lancet Neurology. 2016;15(2):174-184. doi:10.1016/S1474-4422(15)00338-5.
SSGAC
Social Science Genetics Association Consortium
Website: http://www.thessgac.org/
Publications from the HRS Bibliography
Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 2016;533(7604):539-42. doi:10.1038/nature17671.
http://www.ncbi.nlm.nih.gov/pubmed/27225129?dopt=Abstract
Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Res Hum Genet. 2016;19(5):407-17. doi:10.1017/thg.2016.65.