Genes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States

Highlights
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Polygenic risk for depression predicts late life exposure to chronic stressors.

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Women's results suggest weak pleiotropy routed through depression.

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These indirect effects are only on baseline stressor variations across individuals.

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Men's patterns indicate direct pleiotropy on late life change in stressors.

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Holistic life course models incorporating these biological effects are needed.