Bayesian variable selection in linear quantile mixed models for longitudinal data with application to macular degeneration.

Year of Publication
2020
Author
Journal
PLoS One
Volume
15
Issue
10
Number of Pages
e0241197
ISSN Number
1932-6203
Abstract

This paper presents a Bayesian analysis of linear mixed models for quantile regression based on a Cholesky decomposition for the covariance matrix of random effects. We develop a Bayesian shrinkage approach to quantile mixed regression models using a Bayesian adaptive lasso and an extended Bayesian adaptive group lasso. We also consider variable selection procedures for both fixed and random effects in a linear quantile mixed model via the Bayesian adaptive lasso and extended Bayesian adaptive group lasso with spike and slab priors. To improve mixing of the Markov chains, a simple and efficient partially collapsed Gibbs sampling algorithm is developed for posterior inference. Simulation experiments and an application to the Age-Related Macular Degeneration Trial data to demonstrate the proposed methods.

DOI
10.1371/journal.pone.0241197
PMID
33104698
PMCID
PMC7588124
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