Genetics of human longevity from incomplete data: New findings from the long life family study.

TitleGenetics of human longevity from incomplete data: New findings from the long life family study.
Publication TypeJournal Article
Year of Publication2018
AuthorsYashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Bagley, O, Stallard, E, Kulminski, AM, Akushevich, I, Fang, F, Wojczynski, MK, Christensen, K, Newman, AB, Boudreau, RM, Province, MA, Thielke, S, Perls, TT, An, P, Elo, I, Ukraintseva, SV
JournalJournals of Gerontology, Series A: Biological Sciences & Medical Sciences
Volume73
Issue11
Pagination1472-1481
Date Published10/2018
ISSN Number1758-535X
KeywordsGenetics, Longevity
Abstract

The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studies of human longevity which differed with respect to whether missing lifespan data were predicted or not predicted. We showed that the use of predicted lifespan is most beneficial when the follow-up period is relatively short. In addition to detection of strong associations of SNPs in APOE, TOMM40, NECTIN2, and APOC1 genes with longevity, we also detected a strong new association with longevity of rs1927465, located between the CYP26A1 and MYOF genes on chromosome 10. The association was confirmed using data from the Health and Retirement Study. We discuss the biological relevance of the detected SNPs to human longevity.

DOI10.1093/gerona/gly057
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/30299504?dopt=Abstract

Alternate JournalJ. Gerontol. A Biol. Sci. Med. Sci.
Citation Key10003
PubMed ID30299504
PubMed Central IDPMC6175028