Genetic architecture of socioeconomic outcomes: Educational attainment, occupational status, and wealth.

TitleGenetic architecture of socioeconomic outcomes: Educational attainment, occupational status, and wealth.
Publication TypeJournal Article
Year of Publication2019
AuthorsLiu, H
JournalSocial Science Research
Volume82
Pagination137-147
ISSN Number1096-0317
KeywordsEducation, Employment and Labor Force, Genetics, Socioeconomic factors
Abstract

This study takes a socio-genomic approach to examine the complex relationships among three important socioeconomic outcomes: educational attainment, occupational status, and wealth. Using more than 8,000 genetic samples from the Health and Retirement study, it first estimates the collective influence of genetic variants across the whole human genome to each of the three socioeconomic outcomes. It then tests genetic correlations among three socioeconomic outcomes, and examines the extent to which genetic influences on occupational status and wealth are mediated by educational attainment. Analyses using the genomic-relatedness-matrix restricted maximum likelihood method show significant genetic correlations among the three outcomes, and provide evidence for both mediated and independent genetic influences. A polygenic score analysis demonstrates the utility of findings in socio-genomic studies to address genetic confounding in causal relationships among the three socioeconomic outcomes.

DOI10.1016/j.ssresearch.2019.04.008
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/31300074?dopt=Abstract

Alternate JournalSoc Sci Res
Citation Key10128
PubMed ID31300074