Mortality and Obesity among US Older Adults: The Role of Polygenic Risk

To examine the relationship between obesity and mortality as a function of polygenic risk for obesity among older US adults.Using data from the 1994-2014 Health and Retirement Study in conjunction with genome-wide data, we evaluated the risk of mortality as a function of obesity classification, an individual’s polygenic risk score (PGS) for obesity, and their interaction, stratified by sex. We conducted our analyses using cox proportional hazard models.Among those with an average PGS for obesity (8,143 [68.8 \%]), obese I (HR = 0.7