Are Biological Consequences of Childhood Exposures Detectable in Telomere Length Decades Later?

TitleAre Biological Consequences of Childhood Exposures Detectable in Telomere Length Decades Later?
Publication TypeJournal Article
Year of Publication2020
AuthorsKemp, BR, Ferraro, KF
JournalThe Journals of Gerontology: Series A
Date Published01
ISSN Number1079-5006
KeywordsTelomere length
Abstract

Negative early-life exposures have been linked to a host of poor adult health outcomes, but are such early exposures associated with cellular senescence decades later? This study uses data from the Health and Retirement Study to examine the association between six childhood exposure domains (eg, socioeconomic disadvantage, risky parental behavior) and a biomarker of aging, telomere length, among 4,935 respondents. Telomere length is obtained from DNA of cells found in saliva and is measured as the telomere repeat copy number to single gene copy number ratio (T/S). Men who as children were exposed to risky parental behaviors or who reported risky adolescent behaviors have shorter telomeres (b = −0.03

Notes

glaa019

URLhttps://doi.org/10.1093/gerona/glaa019
DOI10.1093/gerona/glaa019
Citation Key10.1093/gerona/glaa019