Composite diagnostic criteria are problematic for linking potentially distinct populations: the case of frailty

TitleComposite diagnostic criteria are problematic for linking potentially distinct populations: the case of frailty
Publication TypeJournal Article
Year of Publication2020
AuthorsChao, Y-S, Wu, C-J, Wu, H-C, Hsu, H-T, Tsao, L-C, Cheng, Y-P, Lai, Y-C, Chen, W-C
JournalScientific Reports
Volume10
Issue1
Type of ArticleArticle
ISSN Number20452322
KeywordsFrail Elderly, Frailty Phenotype, Residence Characteristics
Abstract

{Composite diagnostic criteria are common in frailty research. We worry distinct populations may be linked to each other due to complicated criteria. We aim to investigate whether distinct populations might be considered similar based on frailty diagnostic criteria. The Functional Domains Model for frailty diagnosis included four domains: physical, nutritive, cognitive and sensory functioning. Health and Retirement Study participants with two or more deficiencies in the domains were diagnosed frail. The survival distributions were analyzed using discrete-time survival analysis. The distributions of the demographic characteristics and survival across the groups diagnosed with frailty were significantly different (p < 0.05). A deficiency in cognitive functioning was associated with the worst survival pattern compared with a deficiency in the other domains (adjusted p < 0.05). The associations of the domains with mortality were cumulative without interactions. Cognitive functioning had the largest effect size for mortality prediction (Odds ratios

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85079339704&doi=10.1038%2fs41598-020-58782-1&partnerID=40&md5=ba7c890ffb416ce5b17f819b2c21936a
DOI10.1038/s41598-020-58782-1
Citation KeyChao2020
PubMed ID32054866
PubMed Central IDPMC7018968