Genes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States

TitleGenes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States
Publication TypeJournal Article
Year of Publication2019
AuthorsDas, A
JournalSocial Science & Medicine
Volume242
Pagination112586
Type of ArticleJournal
ISSN Number0277-9536
KeywordsChronic stressors, Depressive symptoms, genes
Abstract

Highlights
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Polygenic risk for depression predicts late life exposure to chronic stressors.

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Women's results suggest weak pleiotropy routed through depression.

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These indirect effects are only on baseline stressor variations across individuals.

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Men's patterns indicate direct pleiotropy on late life change in stressors.

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Holistic life course models incorporating these biological effects are needed.
URLhttp://www.sciencedirect.com/science/article/pii/S0277953619305817
DOI10.1016/j.socscimed.2019.112586
Citation KeyDAS2019112586