Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.

TitleAssociation of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.
Publication TypeJournal Article
Year of Publication2020
AuthorsSanz-de-Galdeano, A, Terskaya, A, Upegui, A
JournalPLoS One
Volume15
Issue9
Paginatione0239067
Date Published2020
ISSN Number1932-6203
KeywordsBMI, BMI polygenic scores
Abstract

We use data from the National Longitudinal Study of Adolescent to Adult Health and from the Health and Retirement Study to explore how the effect of individuals' genetic predisposition to higher BMI -measured by BMI polygenic scores- changes over the life-cycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases significantly as teenagers transition into adulthood (using the Add Health cohort, born 1974-83). However, this is not the case for individuals aged 55+ who were born in earlier HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably stable as they move into old-age.

DOI10.1371/journal.pone.0239067
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/32941506?dopt=Abstract

Citation Key11137
PubMed ID32941506
PubMed Central IDPMC7497990