Genome-wide association study of suicidal behaviour severity in mood disorders.

TitleGenome-wide association study of suicidal behaviour severity in mood disorders.
Publication TypeJournal Article
Year of Publication2021
AuthorsZai, CC, Fabbri, C, Hosang, GM, Zhang, RSu, Koyama, E, de Luca, V, Tiwari, AK, King, N, Strauss, J, Jones, I, Jones, L, Breen, G, Farmer, AE, McGuffin, P, Vincent, JB, Kennedy, JL, Lewis, CM
JournalWorld Journal of Biological Psychiatry
ISSN Number1814-1412
KeywordsBipolar Disorder, Genome-Wide Association Study, major depressive disorder, Mood Disorders, Suicidal Ideation, suicidality, suicide attempt

OBJECTIVE: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity.

METHODS: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (N = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume.

RESULTS: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.

CONCLUSIONS: Larger sample sizes are required to detect moderate effects.

Citation Key11538
PubMed ID33783297