|Title||Genome-wide association study of suicidal behaviour severity in mood disorders.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Zai, CC, Fabbri, C, Hosang, GM, Zhang, RSu, Koyama, E, de Luca, V, Tiwari, AK, King, N, Strauss, J, Jones, I, Jones, L, Breen, G, Farmer, AE, McGuffin, P, Vincent, JB, Kennedy, JL, Lewis, CM|
|Journal||World Journal of Biological Psychiatry|
|Keywords||Bipolar Disorder, Genome-Wide Association Study, major depressive disorder, Mood Disorders, Suicidal Ideation, suicidality, suicide attempt|
OBJECTIVE: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity.
METHODS: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (N = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume.
RESULTS: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.
CONCLUSIONS: Larger sample sizes are required to detect moderate effects.