Evidence for the Scarr-Rowe Effect on Genetic Expressivity in the Health and Retirement Study.

TitleEvidence for the Scarr-Rowe Effect on Genetic Expressivity in the Health and Retirement Study.
Publication TypeJournal Article
Year of Publication2021
AuthorsMenie, MAWoodley, Peñaherrera-Aguirre, M, Dunkel, CS, Sarraf, MA
JournalTwin Research and Human Genetics
Volume24
Issue2
Pagination110-115
ISSN Number1832-4274
KeywordsG × E interaction, polygenic score, Scarr–Rowe effect
Abstract

The Scarr-Rowe effect is a gene × environment interaction, which is characterized by a negative association between exposure to low socioeconomic status (SES) environments and the additive heritability of cognitive ability. Utilizing a polygenic score for educational attainment (EA3), it was found that the two-way interaction between EA3 and parental educational attainment (EA; used as a proxy for parental SES) was a significant positive predictor of participants' composite cognitive ability (IQ) score (β = .018, SE = .008, p = .028) after controlling hierarchically for the direct effects of (population-stratification-controlled) EA3, parental EA, and 20 distinct interaction terms (10 involving the interactions between the principal components [PCs] and EA3, and 10 involving the interaction between the PCs and parental EA). The presence of this interaction is consistent with the Scarr-Rowe effect, as the expressivity of EA3 on cognitive ability increases with increasing parental EA. No statistically significant sex differences in the effect magnitudes were found, although the effect was significantly present in the female but not male sample.

DOI10.1017/thg.2021.13
Citation Key11545
PubMed ID33818363