New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

TitleNew alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Publication TypeJournal Article
Year of Publication2019
AuthorsEvangelou, E, Gao, H, Chu, C, Ntritsos, G, Blakeley, P, Butts, AR, Pazoki, R, Suzuki, H, Koskeridis, F, Yiorkas, AM, Karaman, I, Elliott, J, Luo, Q, Aeschbacher, S, Bartz, TM, Baumeister, SE, Braund, PS, Brown, MR, Brody, JA, Clarke, T-K, Dimou, N, Faul, J, Homuth, G, Jackson, AU, Kentistou, KA, Joshi, PK, Lemaitre, RN, Lind, PA, Lyytikäinen, L-P, Mangino, M, Milaneschi, Y, Nelson, CP, Nolte, IM, Perälä, M-M, Polasek, O, Porteous, DJ, Ratliff, SM, Smith, JA, Stančáková, A, Teumer, A, Tuominen, S, Thériault, S, Vangipurapu, J, Whitfield, JB, Wood, A, Yao, J, Yu, B, Zhao, W, Arking, DE, Auvinen, J, Liu, C, Männikkö, M, Risch, L, Rotter, JI, Snieder, H, Veijola, J, Blakemore, AI, Boehnke, M, Campbell, H, Conen, D, Eriksson, JG, Grabe, H-J, Guo, X, van der Harst, P, Hartman, CA, Hayward, C, Heath, AC, Järvelin, M-R, Kähönen, M, Kardia, SLR, Kühne, M, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Martin, NG, Oldehinkel, AJ, Penninx, BWJH, Psaty, BM, Raitakari, OT, Rudan, I, Samani, NJ, Scott, LJ, Spector, T, Verweij, N, Weir, DR, Wilson, JF, Levy, D, Tzoulaki, I, Bell, JD, Matthews, PM, Rothenfluh, A, Desrivières, S, Schumann, G, Elliott, P
JournalNature Human Behaviour
Volume3
Issue9
Pagination950-961
ISSN Number2397-3374
KeywordsAdult, Aged, Alcohol Drinking, Alcoholism, Brain, Female, genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia, Whites
Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

DOI10.1038/s41562-019-0653-z
Citation Key12123
PubMed ID31358974
PubMed Central IDPMC7711277
Grant ListMC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
R01 HL120393 / HL / NHLBI NIH HHS / United States
U01 HL120393 / HL / NHLBI NIH HHS / United States
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
U54 EB020403 / EB / NIBIB NIH HHS / United States
R21 DA040439 / DA / NIDA NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
MR/R026505/1 / MRC_ / Medical Research Council / United Kingdom
MC_QA137853 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
R01 MH085772 / MH / NIMH NIH HHS / United States
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
MR/R00465X/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
G0700704 / MRC_ / Medical Research Council / United Kingdom
R01 AA026818 / AA / NIAAA NIH HHS / United States