Title | New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Evangelou, E, Gao, H, Chu, C, Ntritsos, G, Blakeley, P, Butts, AR, Pazoki, R, Suzuki, H, Koskeridis, F, Yiorkas, AM, Karaman, I, Elliott, J, Luo, Q, Aeschbacher, S, Bartz, TM, Baumeister, SE, Braund, PS, Brown, MR, Brody, JA, Clarke, T-K, Dimou, N, Faul, J, Homuth, G, Jackson, AU, Kentistou, KA, Joshi, PK, Lemaitre, RN, Lind, PA, Lyytikäinen, L-P, Mangino, M, Milaneschi, Y, Nelson, CP, Nolte, IM, Perälä, M-M, Polasek, O, Porteous, DJ, Ratliff, SM, Smith, JA, Stančáková, A, Teumer, A, Tuominen, S, Thériault, S, Vangipurapu, J, Whitfield, JB, Wood, A, Yao, J, Yu, B, Zhao, W, Arking, DE, Auvinen, J, Liu, C, Männikkö, M, Risch, L, Rotter, JI, Snieder, H, Veijola, J, Blakemore, AI, Boehnke, M, Campbell, H, Conen, D, Eriksson, JG, Grabe, H-J, Guo, X, van der Harst, P, Hartman, CA, Hayward, C, Heath, AC, Järvelin, M-R, Kähönen, M, Kardia, SLR, Kühne, M, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Martin, NG, Oldehinkel, AJ, Penninx, BWJH, Psaty, BM, Raitakari, OT, Rudan, I, Samani, NJ, Scott, LJ, Spector, T, Verweij, N, Weir, DR, Wilson, JF, Levy, D, Tzoulaki, I, Bell, JD, Matthews, PM, Rothenfluh, A, Desrivières, S, Schumann, G, Elliott, P |
Journal | Nature Human Behaviour |
Volume | 3 |
Issue | 9 |
Pagination | 950-961 |
ISSN Number | 2397-3374 |
Keywords | Adult, Aged, Alcohol Drinking, Alcoholism, Brain, Female, genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia, Whites |
Abstract | Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia. |
DOI | 10.1038/s41562-019-0653-z |
Citation Key | 12123 |
PubMed ID | 31358974 |
PubMed Central ID | PMC7711277 |
Grant List | MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom R01 HL120393 / HL / NHLBI NIH HHS / United States U01 HL120393 / HL / NHLBI NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom U54 EB020403 / EB / NIBIB NIH HHS / United States R21 DA040439 / DA / NIDA NIH HHS / United States U01 DK062370 / DK / NIDDK NIH HHS / United States MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom MR/R026505/1 / MRC_ / Medical Research Council / United Kingdom MC_QA137853 / MRC_ / Medical Research Council / United Kingdom U01 HL130114 / HL / NHLBI NIH HHS / United States R01 MH085772 / MH / NIMH NIH HHS / United States MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom MR/R00465X/1 / MRC_ / Medical Research Council / United Kingdom R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States G0700704 / MRC_ / Medical Research Council / United Kingdom R01 AA026818 / AA / NIAAA NIH HHS / United States |