|Title||Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Westbrook, A, Zhang, R, Shi, M, Razavi, AC, Huang, Z, Chen, J, He, J, Kelly, TN, Shen, Y, Li, C|
|Journal||The Journals of Gerontology, Series A|
|Keywords||Kidney disease, Kidney function, Telomere|
We aimed to evaluate associations of baseline telomere length with overall and annual change in estimated glomerular filtration rate (eGFR) and trajectory of kidney function during an 8-year follow-up. A total of 3,964 participants of the Health and Retirement Study (HRS) were included. We identified three trajectory groups of kidney function: consistently normal (n=1,163 or 29.3%), normal to impaired (n=2,306 or 58.2%), and consistently impaired groups (n=495 or 12.5%). After controlling for age, sex, race, education, smoking, drinking, diabetes, heart disease, blood pressure, body mass index, total cholesterol, and hemoglobin A1c, participants with longer telomere length were 20% less likely (odds ratio [OR]=0.80, 95% confidence interval [CI]: 0.69-0.93, P=0.003) to have a normal to impaired kidney function trajectory than a consistently normal function trajectory. Telomere length was not associated with changing rate of eGFR over 8 years (P=0.45). Participants with longer telomere length were more likely to have consistently normal kidney function.