| Title | Women with lower systemic inflammation demonstrate steeper cognitive decline with age: Results from a large prospective, longitudinal sample |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Noss, MMoloci, Millwood, SN, Kuhlman, KR |
| Journal | Brain, Behavior, & Immunity - Health |
| Volume | 22 |
| Pagination | 100465 |
| ISSN Number | 2666-3546 |
| Keywords | C-reactive protein, Cognitive decline, CRP, Neurodegeneration, sex-related disparities, Women's Health |
| Abstract | Men and women experience large disparities in prevalence, detection, and clinical course of neurodegenerative diseases. Inflammation has been implicated in the pathogenesis of neurodegenerative diseases, yet there is a paucity of literature documenting sex differences in this phenomenon in prospective, longitudinal studies. Methods Participants were 4217 non-smoking individuals (62.2% female; aged 46–91 at enrollment) enrolled in the Health and Retirement Study who provided dried blood spots and completed a standardized assessment of cognitive function 3 times across 8 years. Inflammation was indexed using C-reactive protein (CRP). Results Higher CRP was associated with lower concurrent cognitive function |
| DOI | 10.1016/j.bbih.2022.100465 |
| Citation Key | NOSS2022100465 |
