|Title||The Influence of the Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Zeng, B, Yue, Y, Liu, T, Ahn, H, Li, C|
|Journal||Clinical Nursing Research|
|Keywords||Brain-Derived Neurotrophic Factor, Depressive symptoms, Diabetes, Grip strength, Physical activity|
The rs6265 in the (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = -.15) and stronger grip strength (β = -.02) were independently associated with depression. Although the interaction between rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = -.19) and male Met carriers (β = -.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = -.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.