Association of Long-Term Body Weight Variability With Dementia: A Prospective Study.

TitleAssociation of Long-Term Body Weight Variability With Dementia: A Prospective Study.
Publication TypeJournal Article
Year of Publication2022
AuthorsChen, H, Zhou, T, Guo, J, Ji, JS, Huang, L, Xu, W, Zuo, G, Lv, X, Zheng, Y, Hofman, A, Ma, Y, Yuan, C
JournalThe Journals of Gerontology, Series A
ISSN Number1758-535X
KeywordsBody Weight, Proportional Hazards Models, Prospective Studies, Risk Factors, Weight Loss

BACKGROUND: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.

METHODS: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).

RESULTS: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis.

CONCLUSION: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.

Citation Key12788
PubMed ID34908120
PubMed Central IDPMC9536437
Grant ListU01 AG009740 / AG / NIA NIH HHS / United States
/ / Zhejiang University Education Foundation Global Partnership Fund /