|Title||Association of Long-Term Body Weight Variability With Dementia: A Prospective Study.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Chen, H, Zhou, T, Guo, J, Ji, JS, Huang, L, Xu, W, Zuo, G, Lv, X, Zheng, Y, Hofman, A, Ma, Y, Yuan, C|
|Journal||The Journals of Gerontology, Series A|
|Keywords||Body Weight, Proportional Hazards Models, Prospective Studies, Risk Factors, Weight Loss|
BACKGROUND: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined.
METHODS: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI).
RESULTS: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis.
CONCLUSION: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.
|PubMed Central ID||PMC9536437|
|Grant List||U01 AG009740 / AG / NIA NIH HHS / United States |
/ / Zhejiang University Education Foundation Global Partnership Fund /