|Title||Multidimensional trajectories of multimorbidity, functional status, cognitive performance, and depressive symptoms among diverse groups of older adults.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Quiñones, AR, Nagel, CL, Botoseneanu, A, Newsom, JT, Dorr, DA, Kaye, J, Thielke, SM, Allore, HG|
|Journal||Journal of Multimorbidity and Comorbidity|
|Keywords||Cognition, depression, joint trajectories, multimorbidity|
BACKGROUND: Inter-relationships between multimorbidity and geriatric syndromes are poorly understood. This study assesses heterogeneity in joint trajectories of somatic disease, functional status, cognitive performance, and depressive symptomatology.
METHODS: We analyzed 16 years of longitudinal data from the Health and Retirement Study (HRS, 1998-2016) for n = 11,565 older adults (≥65 years) in the United States. Group-based mixture modeling identified latent clusters of older adults following similar joint trajectories across domains.
RESULTS: We identified four distinct multidimensional trajectory groups: (1) (32.7% of the sample; mean = 0.60 conditions at age 65, 2.1 conditions at age 90) had limited deterioration; (2) (32.9%; mean = 2.3 conditions at age 65, 4.0 at age 90) had minimal deterioration; (3) (19.9%; mean = 1.3 conditions at age 65, 2.7 at age 90) had moderate depressive symptomatology and functional impariments with worsening cognitive performance; (4) (14.1%; mean = 3.3 conditions at age 65; 4.7 at age 90) had substantial functional limitation and high depressive symptomatology with worsening cognitive performance. Black and Hispanic race/ethnicity, lower wealth, lower education, male sex, and smoking history were significantly associated with membership in the two classes.
CONCLUSIONS: There is substantial heterogeneity in combined trajectories of interrelated health domains in late life. Membership in the two most impaired classes was more likely for minoritized older adults.
|PubMed Central ID||PMC9720836|
|Grant List||P30 AG066508 / AG / NIA NIH HHS / United States|