Longitudinal body weight dynamics in relation to cognitive decline over two decades: A prospective cohort study.

TitleLongitudinal body weight dynamics in relation to cognitive decline over two decades: A prospective cohort study.
Publication TypeJournal Article
Year of Publication2023
AuthorsZhou, T, Chen, H, Huang, Y, Wang, B, Zheng, Y, Wang, L, Rong, S, Ma, Y, Yuan, C
JournalObesity (Silver Spring)
Date Published2023 Mar
ISSN Number1930-739X
KeywordsAged, Body Weight, Cognitive Dysfunction, Humans, Longitudinal Studies, Middle Aged, Prospective Studies, Weight Gain, Weight Loss

OBJECTIVE: The aim of this study was to investigate the associations of body weight change (BWC) and body weight variability (BWV) with changes in cognitive function.

METHODS: In 10,340 Health and Retirement Study participants (mean age: 68.0 years), body weight was reported biennially from 1993/1994 to 2016, and cognitive function was measured biennially from 1998 to 2016. We calculated BWC and BWV as the slope and root-mean-square error by regressing body weight on time for each individual. BWC was categorized by quintiles (Q): stable weight (Q2 to Q4), weight loss (Q1), and weight gain (Q5). BWV was categorized by tertiles. We used linear mixed regression models to assess associations with cognitive change.

RESULTS: Compared with stable weight (median: 0 kg/y), weight loss (median: -1.3 kg/y) predicted faster cognitive decline as demonstrated by mean difference of -0.023 (95% CI: -0.027 to -0.019) in cognitive change z score per year, whereas weight gain (median: 1 kg/y) was related to slower cognitive decline (β = 0.006; 95% CI: 0.003 to 0.009). Larger BWV was also associated with faster cognitive decline (β comparing the top with bottom tertile = -0.003; 95% CI: -0.006 to -0.0002). Similar associations were observed for episodic and working memory.

CONCLUSIONS: Weight loss and large BWV over a long time independently predicted faster cognitive decline in middle-aged and older adults, underscoring the importance of long-term dynamic body weight monitoring.

User Guide Notes


Alternate JournalObesity (Silver Spring)
Citation Key13181
PubMed ID36782381