Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations.

TitleApolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations.
Publication TypeJournal Article
Year of Publication2023
AuthorsLlibre-Guerra, JJ, Li, J, Qian, Y, Llibre-Rodriguez, Jde Jesús, Jiménez-Velázquez, IZ, Acosta, D, Salas, A, Llibre-Guerra, JCarlos, Valvuerdi, A, Harrati, A, Weiss, J, Liu, M-M, Dow, WH
JournalAlzheimers Dement
ISSN Number1552-5279
KeywordsAged, Alleles, Alzheimer disease, Apolipoprotein E4, Apolipoproteins E, Caribbean Region, Female, Genotype, Hispanic or Latino, Humans, Male

INTRODUCTION: Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations.

METHODS: We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non-Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample.

RESULTS: Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%-25.4%), but was substantially higher in AAs (33.6%; P < 0.001). APOE ε4 carriers had higher dementia prevalence across all groups.

DISCUSSION: APOE ε4 was similarly associated with increased relative risk of dementia and lower memory performance in all subsamples.

Citation Key13350
PubMed ID35661582
PubMed Central IDPMC9719569
Grant List / WT_ / Wellcome Trust / United Kingdom
K01 AG066946 / AG / NIA NIH HHS / United States
K01 AG073526 / AG / NIA NIH HHS / United States
R01 AG064778 / AG / NIA NIH HHS / United States