Personality and Risk of Incident Stroke in 6 Prospective Studies.

TitlePersonality and Risk of Incident Stroke in 6 Prospective Studies.
Publication TypeJournal Article
Year of Publication2023
AuthorsStephan, Y, Sutin, AR, Luchetti, M, Aschwanden, D, Terracciano, A
ISSN Number1524-4628
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Humans, Longitudinal Studies, Middle Aged, Neuroticism, Personality, Prospective Studies, Stroke, United States, Young Adult

BACKGROUND: A large literature has examined a broad range of factors associated with increased risk of stroke. Few studies, however, have examined the association between personality and stroke. The present study adopted a systematic approach using a multi-cohort design to examine the associations between 5-Factor Model personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and incident stroke using data from 6 large longitudinal samples of adults.

METHODS: Participants (age range: 16-104 years old, N=58 105) were from the MIDUS (Midlife in the United States) Study, the HRS (Health and Retirement Study), The US (Understanding Society) study, the WLS (Wisconsin Longitudinal Study), the NHATS (National Health and Aging Trends Study), and the LISS (Longitudinal Internet Studies for the Social Sciences). Personality traits, demographic factors, clinical and behavioral risk factors were assessed at baseline; stroke incidence was tracked over 7 to 20 years follow-up.

RESULTS: Meta-analyses indicated that higher neuroticism was related to a higher risk of incident stroke (hazard ratio, 1.15 [95% CI, 1.10-1.20]; <0.001), whereas higher conscientiousness was protective (HR, 0.89 [95% CI, 0.85-0.93]; <0.001). Additional meta-analyses indicated that BMI, diabetes, blood pressure, physical inactivity, and smoking as additional covariates partially accounted for these associations. Extraversion, openness, and agreeableness were unrelated to stroke incidence.

CONCLUSIONS: Similar to other cardiovascular and neurological conditions, higher neuroticism is a risk factor for stroke incidence, whereas higher conscientiousness is a protective factor.

Citation Key13431
PubMed ID37325920
Grant ListR01 AG068093 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
P01 AG020166 / AG / NIA NIH HHS / United States
U19 AG051426 / AG / NIA NIH HHS / United States
M01 RR023942 / RR / NCRR NIH HHS / United States
M01 RR000865 / RR / NCRR NIH HHS / United States
UL1 TR000427 / TR / NCATS NIH HHS / United States
U01 AG032947 / AG / NIA NIH HHS / United States
R01 AG053297 / AG / NIA NIH HHS / United States