Objectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US.

TitleObjectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US.
Publication TypeJournal Article
Year of Publication2023
AuthorsKilleen, OJ, Zhou, Y, Ehrlich, JR
JournalJAMA Ophthalmology
Volume141
Issue8
Pagination786-790
ISSN Number2168-6173
Keywordsblindness, Dementia, Vision Disorders, Visually Impaired Persons
Abstract

IMPORTANCE: Estimates of the association between visual impairment (VI) and dementia in the US population are based on self-reported survey data or measures of visual function that are at least 15 years old. Older adults are at high risk of VI and dementia so there is a need for up-to-date national estimates based on objective assessments.

OBJECTIVE: To estimate the association between VI and dementia in older US adults based on objective visual and cognitive function testing.

DESIGN, SETTING, AND PARTICIPANTS: This secondary analysis of the 2021 National Health and Aging Trends Study (NHATS), a population-based, nationally representative panel study, included 3817 respondents 71 years and older. Data were analyzed from January to March 2023.

INTERVENTION: In 2021, NHATS incorporated tablet-based tests of distance and near visual acuity and contrast sensitivity (CS) with habitual correction.

MAIN OUTCOMES AND MEASURES: VI was defined as distance visual acuity more than 0.30 logMAR, near visual acuity more than 0.30 logMAR, and CS more than 1 SD below the sample mean. Dementia was defined as scoring 1.5 SDs or more below the mean in 1 or more cognitive domains, an AD8 Dementia Screening Interview Score indicating probable dementia, or diagnosed dementia. Poisson regression estimated dementia prevalence ratios adjusted for covariates.

RESULTS: Of 2967 included participants, 1707 (weighted percentage, 55.3%) were female, and the median (IQR) age was 76.9 (77-86) years. The weighted prevalence of dementia was 12.3% (95% CI, 10.9-13.7) and increased with near VI (21.5%; 95% CI, 17.7-25.3), distance VI (mild: 19.1%; 95% CI, 13.0-25.2; moderate, severe, or blind: 32.9%; 95% CI, 24.1- 41.8), and CS impairment (25.9%; 95% CI, 20.5-31.3). Dementia prevalence was higher among participants with near VI and CS impairment than those without (near VI prevalence ratio: 1.40; 95% CI, 1.16-1.69; CS impairment prevalence ratio: 1.31; 95% CI, 1.04-1.66) and among participants with moderate to severe distance VI or blindness (prevalence ratio: 1.72; 95% CI, 1.26-2.35) after adjustment for covariates.

CONCLUSIONS AND RELEVANCE: In this survey study, all types of objectively measured VI were associated with a higher dementia prevalence. As most VI is preventable, prioritizing vision health may be important for optimizing cognitive function.

DOI10.1001/jamaophthalmol.2023.2854
Citation Key13573
PubMed ID37440238
PubMed Central IDPMC10346499