The role of smoking, obesity and physical inactivity in cognitive performance and decline: a multi-cohort study.

TitleThe role of smoking, obesity and physical inactivity in cognitive performance and decline: a multi-cohort study.
Publication TypeJournal Article
Year of PublicationForthcoming
AuthorsHong, C, Liu, Z, Liu, Y, Jin, Y, Luo, Y
JournalThe Journals of Gerontology, Series A, Biological Sciences and Medical Sciences
ISSN Number1758-535X
Keywordsbirth cohort, Cognitive decline, lifestyles.
Abstract

BACKGROUND: Unhealthy lifestyles are recognized contributors to cognitive decline, yet limited evidence focuses on their roles in cognitive decline rate. This study examined the role of smoking, obesity and physical inactivity in cognitive performance and rate of cognitive decline by birth cohort on a global scale.

METHODS: Utilizing data from four prospective cohort studies (CHARLS; ELSA; HRS; and SHARE) across 14 countries, a multi-cohort study was performed. Eligible participants were aged 50 years and older. Linear mixed models were employed to detect the role of smoking, obesity, and physical inactivity in cognitive function domains (epidemic memory, working memory, and time orientation).

RESULTS: Higher scores of cognitive functions were found in participants who engaged in more vigorous physical activity, were non-current smokers, and maintained underweight (e.g., for episodic memory scores in females at 60 years, vigorous physical activity: 0.47, 95%CI: 0.46, 0.49). In addition, a slower rate of cognitive decline was also found in individuals who engaged in moderate or vigorous physical activity, were non-current smokers, and maintained not underweight (e.g., for episodic memory scores changing from 50-70 years old in females, vigorous physical activity: from 0.54 (95%CI: 0.51, 0.57) to 0.40 (95%CI: 0.37, 0.44) and in males from 0.33 (95%CI: 0.30, 0.36) to 0.11 (95%CI: 0.08, 0.14)).

CONCLUSIONS: We confirmed the beneficial impact of healthy lifestyles in preventing cognitive decline and promoting healthy aging. Urgent measures are needed to identify and encourage healthy lifestyles, such as strengthening tobacco control, developing policy on physical activity promotion, and preventing underweight, to minimize worldwide levels of cognitive decline.

DOI10.1093/gerona/glad232
Citation Key13625
PubMed ID37778005