#03611 MHR as a biomarker for kidney function decline and cardiovascular disease in a large cohort of geriatric patients

{The Monocyte- to high-High-Density Lipoprotein Ratio (MHR) has emerged as a potential biomarker of inflammation and cardiovascular risk. This study examines the association between MHR, kidney function, mortality, and the incidence of incident cardiac disease over a four-year period using data from the Health and Retirement Study (HRS).We analyzed 6,453 older adults enrolled in the Health Retirement Study's 2016 Venous Blood Study presenting available data on renal function, history of chronic diseases, and long-term mortality at 4 years. MHR was used either as a continuous variable or categorized into tertiles. Estimated glomerular filtration rate (eGFR) was calculated using the updated CKD-EPI formula. The cross-sectional association between MHR and eGFR was investigated by using weighted linear regression, while the longitudinal association with mortality and heart disease incidence was examined using weighted Cox regression and Fine Gray models. Study covariates included age, sex, ethnicity, smoking status, history of chronic disease at baseline (hypertension, heart failure, diabetes, lung disease, cancer, stroke/TIA), eGFR at baseline, neutrophil-to-lymphocyte ratio, and hemoglobin levels.The median MHR in the study population was 0.40 (0.31-0.47). Increasing MHR was associated with decreasing eGFR in multivariate linear regression models (β