|Title||Survival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Levy, BR, Bavishi, A|
|Journal||J Gerontol B Psychol Sci Soc Sci|
|Date Published||2018 03 02|
|Keywords||Aged, Aged, 80 and over, Aging, Biomarkers, C-reactive protein, Female, Humans, Inflammation, Longevity, Male, Middle Aged, Self Concept, Surveys and Questionnaires, Survival Analysis|
Objective: Previous studies have found that positive self-perceptions of aging (SPA) are associated with longer survival; however, a biological mechanism was unknown. We examined whether C-reactive protein (CRP), a marker of cumulative stress-related inflammation, mediates the relationship between SPA and survival.
Method: The SPA of participants aged 50 and older in the Health and Retirement Study (N = 4,149) were assessed at baseline. Inflammation was measured by the level of CRP 4 years later. Survival was followed for up to 6 years.
Results: As hypothesized, CRP mediated the impact of SPA on survival. Following the steps of a mediation analysis, positive SPA at baseline predicted lower CRP after 4 years (β = -.29, p = .03) and longer survival in the 2 years following the CRP measurement (β = .20, p =.003); additionally, lower CRP predicted longer survival, after adjusting for positive SPA (β = -.02, p = .0001). All models adjusted for baseline age, CRP, health, sex, race, and education.
Discussion: It was found that lower CRP partially mediates the relationship between positive SPA and longer survival. Hence, this study presents a novel pathway to explain the process by which positive SPA extend longevity.
|User Guide Notes|
|Endnote Keywords|| |
Aging/C-reactive protein/Inflammation/Longevity/Mechanism/Mortality/Self-perceptions of aging/Social cognition/Survival
|Endnote ID|| |
|Alternate Journal||J Gerontol B Psychol Sci Soc Sci|
|PubMed Central ID||PMC5927092|
|Grant List||R01 AG032284 / AG / NIA NIH HHS / United States |
U01 AG032284 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States