Survival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity.

TitleSurvival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity.
Publication TypeJournal Article
Year of Publication2018
AuthorsLevy, BR, Bavishi, A
JournalJ Gerontol B Psychol Sci Soc Sci
Volume73
Issue3
Pagination409-412
Date Published2018 03 02
ISSN Number1758-5368
KeywordsAged, Aged, 80 and over, Aging, Biomarkers, C-reactive protein, Female, Humans, Inflammation, Longevity, Male, Middle Aged, Self Concept, Surveys and Questionnaires, Survival Analysis
Abstract

<p><b>Objective: </b>Previous studies have found that positive self-perceptions of aging (SPA) are associated with longer survival; however, a biological mechanism was unknown. We examined whether C-reactive protein (CRP), a marker of cumulative stress-related inflammation, mediates the relationship between SPA and survival.</p><p><b>Method: </b>The SPA of participants aged 50 and older in the Health and Retirement Study (N = 4,149) were assessed at baseline. Inflammation was measured by the level of CRP 4 years later. Survival was followed for up to 6 years.</p><p><b>Results: </b>As hypothesized, CRP mediated the impact of SPA on survival. Following the steps of a mediation analysis, positive SPA at baseline predicted lower CRP after 4 years (β = -.29, p = .03) and longer survival in the 2 years following the CRP measurement (β = .20, p =.003); additionally, lower CRP predicted longer survival, after adjusting for positive SPA (β = -.02, p = .0001). All models adjusted for baseline age, CRP, health, sex, race, and education.</p><p><b>Discussion: </b>It was found that lower CRP partially mediates the relationship between positive SPA and longer survival. Hence, this study presents a novel pathway to explain the process by which positive SPA extend longevity.</p>

Notes

10.1093/geronb/gbw035

URLhttp://psychsocgerontology.oxfordjournals.org/content/early/2016/03/26/geronb.gbw035.abstractN2 -
DOI10.1093/geronb/gbw035
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/27032428?dopt=Abstract

Endnote Keywords

Aging/C-reactive protein/Inflammation/Longevity/Mechanism/Mortality/Self-perceptions of aging/Social cognition/Survival

Endnote ID

999999

Alternate JournalJ Gerontol B Psychol Sci Soc Sci
Citation Key6499
PubMed ID27032428
PubMed Central IDPMC5927092
Grant ListR01 AG032284 / AG / NIA NIH HHS / United States
U01 AG032284 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States