Linking clinical variables to health-related quality of life in Parkinson's disease.

TitleLinking clinical variables to health-related quality of life in Parkinson's disease.
Publication TypeJournal Article
Year of Publication2002
AuthorsChrischilles, EA, Rubenstein, LM, Voelker, MD, Wallace, RB, Rodnitzky, RL
JournalParkinsonism Relat Disord
Date Published2002 Jan
ISSN Number1353-8020
Call Numberpubs_2002_Chrischilles_EParkandRelDis.pdf
KeywordsAged, Cross-Sectional Studies, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Parkinson Disease, Quality of Life

OBJECTIVE: Identify the point-in-time relationship between Parkinson's disease (PD) signs and symptoms and measures of health-related quality of life (HRQL).

BACKGROUND: Clinical measures used in PD assessments traditionally emphasize physical signs and symptoms. We hypothesized that these measures would be strongly associated with the physical function dimensions of HRQL that reflect mental symptoms.

DESIGN/METHODS: A cross-sectional study of 193 neurology clinic PD patients employed self-administered in-clinic and take-home questionnaires and in-person clinical examinations and interviews.

RESULTS: The variance explained by PD physical signs and symptoms was substantial for physical function, but only modest for all other HRQL dimensions. Mental symptoms explained a larger proportion of variance than physical symptoms for 12 of the 14 HRQL measures.

CONCLUSION: PD patients' well-being, general health perceptions, health satisfaction and overall HRQL are strongly influenced by mental health symptoms and more weakly influenced by physical symptoms. Clinical evaluation of PD patients should include mental health and self-reported HRQL assessment.

User Guide Notes

Endnote Keywords

Health Status/Mental Health/Quality of Life/Parkinson disease

Endnote ID


Alternate JournalParkinsonism Relat Disord
Citation Key6825
PubMed ID12039432
Grant ListU01 AG009740 / AG / NIA NIH HHS / United States