Cognitive deficits and the course of major depression in a cohort of middle-aged and older community-dwelling adults.

TitleCognitive deficits and the course of major depression in a cohort of middle-aged and older community-dwelling adults.
Publication TypeJournal Article
Year of Publication2004
AuthorsMojtabai, R, Olfson, M
JournalJ Am Geriatr Soc
Date Published2004 Jul
ISSN Number0002-8614
KeywordsAged, Chi-Square Distribution, Cognition Disorders, Depressive Disorder, Major, Female, Geriatric Assessment, Humans, Interviews as Topic, Logistic Models, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Residence Characteristics, Risk Factors, United States

OBJECTIVES: To examine associations between cognitive deficits and persistent significant depressive symptoms at baseline and 2- and 4-year follow-ups in a sample of community-dwelling middle-aged and older adults.

DESIGN: Prospective cohort study.

SETTING: A U.S. national prospective cohort study of middle-aged and older adults, the Health and Retirement Study.

PARTICIPANTS: A sample of 661 participants of the 1996 wave of the Health and Retirement Study who met criteria for 12-month Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised major depression (MD).

MEASUREMENTS: MD was assessed using the World Health Organization Composite International Diagnostic Interview-Short Form. Persistent significant depressive symptoms were assessed using an eight-item version of the Center for Epidemiological Studies Depression scale.

RESULTS: Cognitive deficits were associated with persistent significant depressive symptoms at follow-up. In a latent state-trait analysis, two stable and strongly correlated traits best explained variations in cognitive functioning and depressive symptoms across assessment points.

CONCLUSION: Trait-like cognitive deficits commonly complicate the course of MD in community-dwelling middle-aged and older adults and may help to explain the persistent course of depressive symptoms in a large subgroup of adults with MD in this age range.

User Guide Notes

Endnote Keywords

Cognition/Depression/Female/Geriatric Assessment/Logistic Models/Prospective Studies/Psychiatric Status Rating Scales/Housing/Risk Factors

Endnote ID


Alternate JournalJ Am Geriatr Soc
Citation Key6978
PubMed ID15209642
Grant ListMH01754 / MH / NIMH NIH HHS / United States
MH56490 / MH / NIMH NIH HHS / United States