|Title||Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Potter, GG, Plassman, BL, Burke, JR, Kabeto, MU, Langa, KM, Llewellyn, DJ, Rogers, MAM, Steffens, DC|
|Journal||Alzheimer's & Dementia|
|Keywords||Activities of Daily Living, African Americans, Age of Onset, Aged, Aged, 80 and over, Caregivers, Cognition Disorders, Cohort Studies, Culture, Dementia, Disability Evaluation, European Continental Ancestry Group, Female, Geriatric Assessment, Health Surveys, Humans, Male, Neuropsychological tests, Observer Variation, Population Surveillance, Predictive Value of Tests, Prevalence, Psychiatric Status Rating Scales, Psychometrics, Registries, Sensitivity and Specificity, Surveys and Questionnaires|
BACKGROUND: The diagnosis of cognitive impairment and dementia must reflect an increasingly diverse and aging United States population. This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment and dementia between African Americans and whites.
METHODS: Participants in the Aging, Demographics, and Memory Study completed in-person dementia evaluations, and were assigned clinical diagnoses (by a consensus panel of dementia experts) of normal; cognitive impairment, not demented (CIND); and dementia. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) total score and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) were used to assess cognitive performance and reported cognitive decline.
RESULTS: A higher CERAD total score was associated with lower odds of CIND and dementia, at comparable ratios between African Americans and whites. Higher IQCODE scores were associated with increased odds of dementia in both African Americans and whites. Higher IQCODE scores were associated with increased odds of CIND among whites, but not among African Americans.
CONCLUSIONS: Cultural differences may influence informant reports of prevalent CIND and dementia. Our findings also highlight the need for more comparative research to establish the cultural validity of measures used to diagnose these conditions.
|Endnote Keywords|| |
CERAD/IQCODE/Cognitive decline/Dementia/African American
|Endnote ID|| |
|PubMed Central ID||PMC2805266|
|Grant List||R01 AG027010 / AG / NIA NIH HHS / United States |
R01 AG027010-03 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
U01 AG09740 / AG / NIA NIH HHS / United States