Title | Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Llewellyn, DJ, Lang, IA, Matthews, FE, Plassman, BL, Rogers, MAM, Morgenstern, LB, Fisher, GG, Kabeto, MU, Langa, KM |
Journal | Alzheimers Res Ther |
Volume | 2 |
Issue | 3 |
Pagination | 19 |
Date Published | 2010 Jun 24 |
ISSN Number | 1758-9193 |
Call Number | newpubs20110418_Llewellyn.pdf |
Abstract | INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression. RESULTS: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001). CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia. |
URL | http://alzres.com/content/2/3/19 |
DOI | 10.1186/alzrt43 |
User Guide Notes | |
Endnote Keywords | Dementia/Vascular dementia/Stroke |
Endnote ID | 24880 |
Alternate Journal | Alzheimers Res Ther |
Citation Key | 7524 |
PubMed ID | 20576093 |
PubMed Central ID | PMC2919699 |
Grant List | MC_U105292687 / MRC_ / Medical Research Council / United Kingdom U01 AG009740 / AG / NIA NIH HHS / United States |