|Title||Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Llewellyn, DJ, Lang, IA, Matthews, FE, Plassman, BL, Rogers, MAM, Morgenstern, LB, Fisher, GG, Kabeto, MU, Langa, KM|
|Journal||Alzheimers Res Ther|
|Date Published||2010 Jun 24|
INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia.
METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression.
RESULTS: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001).
CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia.
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|Alternate Journal||Alzheimers Res Ther|
|PubMed Central ID||PMC2919699|
|Grant List||MC_U105292687 / MRC_ / Medical Research Council / United Kingdom |
U01 AG009740 / AG / NIA NIH HHS / United States