Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.

TitleOperationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.
Publication TypeJournal Article
Year of Publication2011
AuthorsSeshadri, S, Beiser, A, Au, R, Wolf, PA, Evans, DA, Wilson, RS, Petersen, RC, Knopman, DS, Rocca, WA, Kawas, CH, Corrada, MM, Plassman, BL, Langa, KM, Chui, HC
JournalAlzheimers Dement
Volume7
Issue1
Pagination35-52
Date Published2011 Jan
ISSN Number1552-5279
Call Numbernewpubs20110328_Seshadri.pdf
KeywordsAge Factors, Aging, Alzheimer disease, Cognition Disorders, Community Health Planning, Humans, Incidence, Longitudinal Studies, Neuropsychological tests, Prevalence, United States
Abstract

<p>This article focuses on the effects of operational differences in case ascertainment on estimates of prevalence and incidence of cognitive impairment and/or dementia of the Alzheimer type. Experience and insights are discussed by investigators from the Framingham Heart Study, the East Boston Senior Health Project, the Chicago Health and Aging Project, the Mayo Clinic Study of Aging, the Baltimore Longitudinal Study of Aging, and the Aging, Demographics, and Memory Study. There is a general consensus that the single most important factor determining prevalence estimates of Alzheimer's disease (AD) is the severity of cognitive impairment used as a threshold to define cases. Studies that require a level of cognitive impairment in which persons are unable to provide self-care will have much lower estimates than the studies aimed at identifying persons in the earliest stages of AD. There are limited autopsy data from the aforementioned epidemiological studies to address accuracy in the diagnosis of etiological subtype, namely the specification of AD alone or in combination with other types of pathology. However, other community-based cohort studies show that many persons with mild cognitive impairment and also some persons without dementia or mild cognitive impairment meet pathological criteria for AD, thereby suggesting that the number of persons who would benefit from an effective secondary prevention intervention is probably higher than the published prevalence estimates. Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies.</p>

URLhttp://download.journals.elsevierhealth.com/pdfs/journals/1552-5260/PIIS1552526010025148.pdf
DOI10.1016/j.jalz.2010.12.002
User Guide Notes

http://www.ncbi.nlm.nih.gov/pubmed/21255742?dopt=Abstract

Endnote Keywords

Alzheimer disease/cognitive Impairment/PREVALENCE/Incidence/Dementia

Endnote ID

24570

Alternate JournalAlzheimers Dement
Citation Key7563
PubMed ID21255742
PubMed Central IDPMC3039838
Grant ListR01 AG033040-03 / AG / NIA NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
R01 AG021055 / AG / NIA NIH HHS / United States
N01AG02107 / AG / NIA NIH HHS / United States
P50 AG005142 / AG / NIA NIH HHS / United States
R01AG16495 / AG / NIA NIH HHS / United States
R01 AG016495 / AG / NIA NIH HHS / United States
R01 AG034676 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
P50 AG016574 / AG / NIA NIH HHS / United States
P01AG012435 / AG / NIA NIH HHS / United States
R01NS17950 / NS / NINDS NIH HHS / United States
R01AG08122 / AG / NIA NIH HHS / United States
U01AG06786 / AG / NIA NIH HHS / United States
P50AG016574 / AG / NIA NIH HHS / United States
R01AG008325 / AG / NIA NIH HHS / United States
R01 AG008122 / AG / NIA NIH HHS / United States
P01 AG012435 / AG / NIA NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
R01AG033040 / AG / NIA NIH HHS / United States
R01AG021055 / AG / NIA NIH HHS / United States
U01AG009740 / AG / NIA NIH HHS / United States
R01 AG033040 / AG / NIA NIH HHS / United States
R01AG033193 / AG / NIA NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
R01 AG031287-02 / AG / NIA NIH HHS / United States
R01 AG011101 / AG / NIA NIH HHS / United States
R01AG034676 / AG / NIA NIH HHS / United States
R01AG031287 / AG / NIA NIH HHS / United States
P50AG005142 / AG / NIA NIH HHS / United States
N01AG12106 / AG / NIA NIH HHS / United States
R01 AG008122-22 / AG / NIA NIH HHS / United States
R01 AG033193-03 / AG / NIA NIH HHS / United States
R01AG011101 / AG / NIA NIH HHS / United States
U01 AG006786 / AG / NIA NIH HHS / United States
R01 AG031287 / AG / NIA NIH HHS / United States