National estimates of the prevalence of Alzheimer's disease in the United States.

TitleNational estimates of the prevalence of Alzheimer's disease in the United States.
Publication TypeJournal Article
Year of Publication2011
AuthorsBrookmeyer, R, Evans, DA, Hebert, L, Langa, KM, Heeringa, SG, Plassman, BL, Kukull, W
JournalAlzheimer's & Dementia
Volume7
Issue1
Pagination61-73
ISSN Number1552-5279
Call Numbernewpubs20110328_Brookmeyer.pdf
KeywordsAge Factors, Alzheimer disease, Community Health Planning, Data collection, Humans, Incidence, Models, Statistical, Prevalence, Sampling Studies, United States
Abstract

Several methods of estimating prevalence of dementia are presented in this article. For both Brookmeyer and the Chicago Health and Aging project (CHAP), the estimates of prevalence are derived statistically, forward calculating from incidence and survival figures. The choice of incidence rates on which to build the estimates may be critical. Brookmeyer used incidence rates from several published studies, whereas the CHAP investigators applied the incidence rates observed in their own cohort. The Aging, Demographics, and Memory Study (ADAMS) and the East Boston Senior Health Project (EBSHP) were sample surveys designed to ascertain the prevalence of Alzheimer's disease and dementia. ADAMS obtained direct estimates by relying on probability sampling nationwide. EBSHP relied on projection of localized prevalence estimates to the national population. The sampling techniques of ADAMS and EBSHP were rather similar, whereas their disease definitions were not. By contrast, EBSPH and CHAP have similar disease definitions internally, but use different calculation techniques, and yet arrive at similar prevalence estimates, which are considerably greater than those obtained by either Brookmeyer or ADAMS. Choice of disease definition may play the larger role in explaining differences in observed prevalence between these studies.

DOI10.1016/j.jalz.2010.11.007
Endnote Keywords

Alzheimer disease/Dementia/Cognitive impairment/Prevalence/Population-based/Projection/Probability/sampling

Endnote ID

24580

Citation Key7564
PubMed ID21255744
PubMed Central IDPMC3052294
Grant ListR01 AG011101-09 / AG / NIA NIH HHS / United States
R01 AG027010-01 / AG / NIA NIH HHS / United States
N01AG02107 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
U01AG016976 / AG / NIA NIH HHS / United States
U01 AG016976 / AG / NIA NIH HHS / United States
U01 AG016976-09 / AG / NIA NIH HHS / United States
R01AG027010 / AG / NIA NIH HHS / United States
R01 AG027010 / AG / NIA NIH HHS / United States
U01AG009740 / AG / NIA NIH HHS / United States
U01 AG009740-10 / AG / NIA NIH HHS / United States
R01 AG011101 / AG / NIA NIH HHS / United States
N01AG12106 / AG / NIA NIH HHS / United States
R01AG011101 / AG / NIA NIH HHS / United States