Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States.

TitleTrends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States.
Publication TypeJournal Article
Year of Publication2011
AuthorsRocca, WA, Petersen, RC, Knopman, DS, Hebert, L, Evans, DA, Hall, KS, Gao, S, Unverzagt, FW, Langa, KM, Larson, EB, White, LR
JournalAlzheimer's & Dementia
Volume7
Issue1
Pagination80-93
ISSN Number1552-5279
Call Numbernewpubs20110328_Rocca.pdf
KeywordsAge Factors, Alzheimer disease, Cognition Disorders, Cohort Studies, Community Health Planning, Dementia, Humans, Incidence, Prevalence, Residence Characteristics, Retrospective Studies, Time Factors, United States
Abstract

Declines in heart disease and stroke mortality rates are conventionally attributed to reductions in cigarette smoking, recognition and treatment of hypertension and diabetes, effective medications to improve serum lipid levels and to reduce clot formation, and general lifestyle improvements. Recent evidence implicates these and other cerebrovascular factors in the development of a substantial proportion of dementia cases. Analyses were undertaken to determine whether corresponding declines in age-specific prevalence and incidence rates for dementia and cognitive impairment have occurred in recent years. Data spanning 1 or 2 decades were examined from community-based epidemiological studies in Minnesota, Illinois, and Indiana, and from the Health and Retirement Study, which is a national survey. Although some decline was observed in the Minnesota cohort, no statistically significant trends were apparent in the community studies. A significant reduction in cognitive impairment measured by neuropsychological testing was identified in the national survey. Cautious optimism appears justified.

DOI10.1016/j.jalz.2010.11.002
Endnote Keywords

Alzheimers disease/Dementia/Cognitive impairment/Prevalence/Incidence/Time trends

Endnote ID

24610

Citation Key7567
PubMed ID21255746
PubMed Central IDPMC3026476
Grant ListR03 AG029652 / AG / NIA NIH HHS / United States
R01 AG009956-19 / AG / NIA NIH HHS / United States
R01 AG019805 / AG / NIA NIH HHS / United States
R01 AG034676 / AG / NIA NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
K08 AG019180-05 / AG / NIA NIH HHS / United States
R01 AG009956 / AG / NIA NIH HHS / United States
K08AG019180 / AG / NIA NIH HHS / United States
R01AG015911 / AG / NIA NIH HHS / United States
R01 AG015911-05 / AG / NIA NIH HHS / United States
K08 AG019180 / AG / NIA NIH HHS / United States
R01 AG027010-03 / AG / NIA NIH HHS / United States
U01AG019349 / AG / NIA NIH HHS / United States
U01 AG006781-18 / AG / NIA NIH HHS / United States
R01AG027010 / AG / NIA NIH HHS / United States
R01AG009956 / AG / NIA NIH HHS / United States
R01 AG019805-03S2 / AG / NIA NIH HHS / United States
U01AG06786 / AG / NIA NIH HHS / United States
U01 AG019349 / AG / NIA NIH HHS / United States
U01AG006781 / AG / NIA NIH HHS / United States
R01 AG017155-05S1 / AG / NIA NIH HHS / United States
R03AG029652 / AG / NIA NIH HHS / United States
U01 AG019349-06A1 / AG / NIA NIH HHS / United States
R01 AG015911 / AG / NIA NIH HHS / United States
U01 AG006786-14 / AG / NIA NIH HHS / United States
U01AG017155 / AG / NIA NIH HHS / United States
R01 AG027010 / AG / NIA NIH HHS / United States
U01 AG006781 / AG / NIA NIH HHS / United States
U01AG009740 / AG / NIA NIH HHS / United States
R03 AG029652-02 / AG / NIA NIH HHS / United States
U01 AG017155 / AG / NIA NIH HHS / United States
R01AG019805 / AG / NIA NIH HHS / United States
R01 AG011101 / AG / NIA NIH HHS / United States
R01AG034676 / AG / NIA NIH HHS / United States
R01 AG011101-16 / AG / NIA NIH HHS / United States
R01 AG034676-45 / AG / NIA NIH HHS / United States
R01 AG017155 / AG / NIA NIH HHS / United States
R01AG011101 / AG / NIA NIH HHS / United States
U01 AG006786 / AG / NIA NIH HHS / United States
U01 AG009740-21 / AG / NIA NIH HHS / United States