|Title||Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Brainerd, CJ, Reyna, VF, Petersen, RC, Smith, GE, Taub, ES|
|Keywords||Aged, Aged, 80 and over, Aging, Analysis of Variance, Apolipoprotein E4, Cognitive Dysfunction, Dementia, Female, Gene Frequency, Genetic Markers, Genetic Testing, Genotype, Humans, Male, National Institute on Aging (U.S.), Neuropsychological tests, Reference Values, Reproducibility of Results, Risk Factors, United States|
OBJECTIVE: Although the ε4 allele of the apolipoprotein E (APOE) genotype is a known risk factor for Alzheimer's dementia (AD), prior findings on whether it is also a risk factor for mild cognitive impairment (MCI) have been inconsistent. We tested two contrasting explanations: (a) an ε4-AD specificity hypothesis, and (b) a measurement insensitivity hypothesis.
METHOD: The frequency of the ε4 allele was investigated in older adults (mean age > 70) with various types of cognitive impairment (including MCI) and various types of dementia (including AD) with the aging, demographics, and memory study (ADAMS) of the National Institute on Aging's Health and Retirement Study (HRS). The ADAMS controls sources of Type I and Type II error that are posited in the ε4-AD specificity hypothesis and the measurement insensitivity hypothesis, and it is the only nationally representative data set on aging and cognitive impairment.
RESULTS: ε4 was a reliable predictor of MCI, with a frequency of 32% in MCI subjects versus 20% in healthy control subjects. This link was specific to MCI because ε4 was not a risk factor for other forms of cognitive impairment without dementia.
CONCLUSIONS: The results support the measurement insensitivity hypothesis rather than the ε4-AD specificity hypothesis and are consistent with recent research showing modest reductions in cognitive performance among normal functioning ε4 carriers.
Brainerd, Charles J Reyna, Valerie F Petersen, Ronald C Smith, Glenn E Taub, Emily S 1RC1AG036915-01/AG/NIA NIH HHS/United States U01AG009740/AG/NIA NIH HHS/United States Research Support, N.I.H., Extramural United States Neuropsychology. 2011 Nov;25(6):679-89.
|Endnote Keywords|| |
Aging/Analysis of Variance/Apolipoprotein E4/genetics/genetics/Dementia/Gene Frequency/Genetic Markers/Genetic Testing/Genotype/Mild Cognitive Impairment/Neuropsychological Tests/Reference Values/Reproducibility of Results/Risk Factors/Alzheimer disease/epsilon4 allele
|Endnote ID|| |
|Grant List||1RC1AG036915-01 / AG / NIA NIH HHS / United States |
U01AG009740 / AG / NIA NIH HHS / United States